Document Detail

Effect of changes in renal circulation on serum uric acid levels in women with twin pregnancy.
MedLine Citation:
PMID:  20556458     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We examined the relationship between serum uric acid levels and changes in renal circulation in women with twin pregnancy compared with those in women with singleton pregnancy.
METHODS: The Doppler waveforms of the bilateral maternal main renal arteries were obtained from 15 women at 37-38 weeks of nonpreeclamptic twin pregnancy and 16 healthy women at the same gestational age of singleton pregnancy. The resistance index (RI), pulsatility index (PI), and acceleration time were determined.
RESULTS: The mean serum uric acid level in the twin pregnancy group was significantly higher than that in the singleton pregnancy group (5.0 ± 0.9 vs. 3.7 ± 0.6 mg/dl, P < 0.01). Although there were no significant differences in the RI or PI levels between the singleton and twin pregnancy groups, the acceleration time in the twin pregnancy group was significantly prolonged compared with that in the singleton pregnancy group (82.2 ± 29 vs. 59.9 ± 17 ms, P = 0.01). There was a significant correlation between serum uric acid levels and acceleration times (r(2) = 0.55, P < 0.01).
CONCLUSION: The changes in renal circulation may be one of the possible mechanisms leading to hyperuricemia in women with twin pregnancies.
Miwa Igarashi; Hidehiko Miyake; Shunji Suzuki
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Publication Detail:
Type:  Journal Article     Date:  2010-06-17
Journal Detail:
Title:  Clinical and experimental nephrology     Volume:  14     ISSN:  1437-7799     ISO Abbreviation:  Clin. Exp. Nephrol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-06     Completed Date:  2011-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709923     Medline TA:  Clin Exp Nephrol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  436-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, 5-11-12 Tateishi, Katsushika-ku, Tokyo, 124-0012, Japan.
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MeSH Terms
Gestational Age
Hyperuricemia* / blood,  etiology
Pregnancy / blood*
Pregnancy, Multiple / blood*
Renal Artery / anatomy & histology
Renal Circulation / physiology*
Uric Acid / blood*
Reg. No./Substance:
69-93-2/Uric Acid

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