Document Detail

Effect of changes in dietary sodium and potassium on blood pressure and cellular electrolyte handling in young normotensive subjects.
MedLine Citation:
PMID:  2415579     Owner:  NLM     Status:  MEDLINE    
In a study on 22 normotensive male subjects, a change in dietary sodium intake from 29.6 +/- 6.0 to 332.5 +/- 13.9 mmol/day (mean +/- s.e.m.), over 7 days, was associated with a significant rise in supine and standing systolic blood pressure and a fall in sodium pump activity. Intracellular sodium remained constant, while intracellular potassium fell. These changes appeared to be reversed by the addition of potassium (96 mmol/day) to the high sodium diet. The 12 subjects with a family history of essential hypertension, as determined by measurement of parental blood pressure, did not differ in their response from those whose parents were normotensive.
P L Weissberg; M J West; M J Kendall; M Ingram; K L Woods
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  3     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-01-22     Completed Date:  1986-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  475-80     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Erythrocytes / drug effects,  metabolism
Hypertension / genetics,  physiopathology
Intracellular Fluid / metabolism
Ion Channels / drug effects*,  metabolism
Potassium / administration & dosage*,  metabolism
Sodium / administration & dosage*,  metabolism
Water-Electrolyte Balance
Reg. No./Substance:
0/Ion Channels; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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