Document Detail


Effect of cerebral spinal fluid suppression for diffusional kurtosis imaging.
MedLine Citation:
PMID:  23034866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the cerebral spinal fluid (CSF) partial volume effect on diffusional kurtosis imaging (DKI) metrics in white matter and cortical gray matter.
MATERIALS AND METHODS: Four healthy volunteers participated in this study. Standard DKI and fluid-attenuated inversion recovery (FLAIR) DKI experiments were performed using a twice-refocused-spin-echo diffusion sequence. The conventional diffusion tensor imaging (DTI) metrics of fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, D[symbol in text], D[symbol in text] together with DKI metrics of mean, axial, and radial kurtosis (MK, K[symbol in text], K[symbol in text], were measured and compared. Single image slices located above the lateral ventricles, with similar anatomical features for each subject, were selected to minimize the effect of CSF from the ventricles.
RESULTS: In white matter, differences of less than 10% were observed between diffusion metrics measured with standard DKI and FLAIR-DKI sequences, suggesting minimal CSF contamination. For gray matter, conventional DTI metrics differed by 19% to 52%, reflecting significant CSF partial volume effects. Kurtosis metrics, however, changed by 11% or less, indicating greater robustness with respect to CSF contamination.
CONCLUSION: Kurtosis metrics are less sensitive to CSF partial voluming in cortical gray matter than conventional diffusion metrics. The kurtosis metrics may then be more specific indicators of changes in tissue microstructure, provided the effect sizes for the changes are comparable.
Authors:
Alicia W Yang; Jens H Jensen; Caixia C Hu; Ali Tabesh; Maria F Falangola; Joseph A Helpern
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-03
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  37     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-08-07     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms
Artifacts*
Brain / anatomy & histology*
Cerebrospinal Fluid / cytology*
Female
Humans
Image Enhancement / methods*
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Subtraction Technique*
Young Adult
Grant Support
ID/Acronym/Agency:
1R01AG027852/AG/NIA NIH HHS; 1R01EB007656/EB/NIBIB NIH HHS; R01 AG027852/AG/NIA NIH HHS; R01 EB007656/EB/NIBIB NIH HHS
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