Document Detail

Effect of ceramic filler content on the mechanical and thermal behaviour of poly-L-lactic acid and poly-L-lactic-co-glycolic acid composites for medical applications.
MedLine Citation:
PMID:  20552389     Owner:  NLM     Status:  MEDLINE    
One main application of resorbable poly-L-lactic acid (PLLA) and poly-L-lactic-co-glycolic acid (PLGA) based materials is in medical implants. In this study composites were made from PLLA and PLGA with hydroxyapatite (HAp) respective beta-tricalcium phosphate (beta-TCP) fillers. The filler content and particle size were varied, and the thermal properties as well as the mechanical strength of the composites were investigated. The composites were made by an extrusion compounding process giving 2-2.5 mm diameter sized profiles. The results verified that the thermal stability of the composites was reasonable during the optimized compounding conditions. Scanning electron microscopy revealed that the fillers were well dispersed in the polymer matrices. The mechanical properties were improved by the addition of the fillers. The optimum mechanical properties for the extruded profiles were obtained with the HAp fillers. The E-modulus was increased from 3.3 to 4.6 GPa by addition of filler particles (30 wt%) whereas the flexural strength was reduced from 133 to 106 MPa.
Behzad Damadzadeh; Hamideh Jabari; Mikael Skrifvars; Karri Airola; Niko Moritz; Pekka K Vallittu
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Publication Detail:
Type:  Journal Article     Date:  2010-06-15
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  21     ISSN:  1573-4838     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-08     Completed Date:  2011-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2523-31     Citation Subset:  IM    
School of Engineering, University of Borås, Allegatan 1, 501 90, Borås, Sweden.
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MeSH Terms
Lactic Acid / chemistry*
Microscopy, Electron, Scanning
Polyglycolic Acid / chemistry*
Polymers / chemistry*
Reg. No./Substance:
0/Ceramics; 0/Polymers; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid

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