Document Detail

Effect of centrifuge-induced artificial gravity and ergometric exercise on cardiovascular deconditioning, myatrophy, and osteoporosis induced by a -6 degrees head-down bedrest.
MedLine Citation:
PMID:  16240530     Owner:  NASA     Status:  MEDLINE    
We have reported that centrifuge-induced artificial gravity with ergometric exercise could reduce developing cardiovascular deconditioning in humans. In the present study, we examined this load could prevent the myatrophy and osteoporosis induced by head-down bedrest for 20 days. Subjects were ten healthy male volunteers with informed consent. They were requested to lie down at -6 degrees for 20 days, and evaluation for cardiovascular deconditioning, myatrophy, and osteoporosis. As the result, high G-load with low intensity exercise suppressed the orthostatic intolerance and increase in serum osteoporotic marker, whereas low G-load with high intensity ergometric exercise maintained the maximal oxygen intake, heart dimension, and prevented myatrophy. The combination of high/low G-load with low/high intensity exercise will determine the optimal protocol for prevention of cardiovascular deconditioning, myatrophy, and osteoporosis.
Satoshi Iwase; Hiroki Takada; Yoriko Watanabe; Koji Ishida; Hiroshi Akima; Keisho Katayama; Mitsunori Iwase; Kaname Hirayanagi; Tomoki Shiozawa; Takafumi Hamaoka; Yoshihisa Masuo; Marc-Antoine Custaud
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology     Volume:  11     ISSN:  1077-9248     ISO Abbreviation:  J Gravit Physiol     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2005-10-21     Completed Date:  2005-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9437868     Medline TA:  J Gravit Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  P243-4     Citation Subset:  S    
Dept. Physiol. II, Aichi Med. Univ., Aichi, Japan.
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MeSH Terms
Amino Acids / urine
Bed Rest / adverse effects*
Biological Markers
Bone Demineralization, Pathologic / prevention & control
Cardiovascular Deconditioning / physiology*
Exercise / physiology*
Fluid Shifts / physiology
Gravity, Altered*
Head-Down Tilt
Heart Rate
Hypotension, Orthostatic / prevention & control
Muscle, Skeletal / physiology
Muscular Atrophy / prevention & control
Oxygen Consumption
Plasma Volume / physiology
Sympathetic Nervous System / physiology
Weightlessness Countermeasures*
Reg. No./Substance:
0/Amino Acids; 0/Biological Markers; 90032-33-0/deoxypyridinoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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