| Effect of centrifuge-induced artificial gravity and ergometric exercise on cardiovascular deconditioning, myatrophy, and osteoporosis induced by a -6 degrees head-down bedrest. | |
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MedLine Citation:
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PMID: 16240530 Owner: NASA Status: MEDLINE |
Abstract/OtherAbstract:
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We have reported that centrifuge-induced artificial gravity with ergometric exercise could reduce developing cardiovascular deconditioning in humans. In the present study, we examined this load could prevent the myatrophy and osteoporosis induced by head-down bedrest for 20 days. Subjects were ten healthy male volunteers with informed consent. They were requested to lie down at -6 degrees for 20 days, and evaluation for cardiovascular deconditioning, myatrophy, and osteoporosis. As the result, high G-load with low intensity exercise suppressed the orthostatic intolerance and increase in serum osteoporotic marker, whereas low G-load with high intensity ergometric exercise maintained the maximal oxygen intake, heart dimension, and prevented myatrophy. The combination of high/low G-load with low/high intensity exercise will determine the optimal protocol for prevention of cardiovascular deconditioning, myatrophy, and osteoporosis. |
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Authors:
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Satoshi Iwase; Hiroki Takada; Yoriko Watanabe; Koji Ishida; Hiroshi Akima; Keisho Katayama; Mitsunori Iwase; Kaname Hirayanagi; Tomoki Shiozawa; Takafumi Hamaoka; Yoshihisa Masuo; Marc-Antoine Custaud |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology Volume: 11 ISSN: 1077-9248 ISO Abbreviation: J Gravit Physiol Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2005-10-21 Completed Date: 2005-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9437868 Medline TA: J Gravit Physiol Country: United States |
Other Details:
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Languages: eng Pagination: P243-4 Citation Subset: S |
Affiliation:
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Dept. Physiol. II, Aichi Med. Univ., Aichi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids / urine Bed Rest / adverse effects* Biological Markers Bone Demineralization, Pathologic / prevention & control Cardiovascular Deconditioning / physiology* Centrifugation Echocardiography Exercise / physiology* Fluid Shifts / physiology Gravity, Altered* Head-Down Tilt Heart Rate Humans Hypergravity* Hypotension, Orthostatic / prevention & control Leg Male Muscle, Skeletal / physiology Muscular Atrophy / prevention & control Oxygen Consumption Plasma Volume / physiology Sympathetic Nervous System / physiology Weightlessness Countermeasures* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Biological Markers; 90032-33-0/deoxypyridinoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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