Document Detail

Effect of centrally administered losartan on gastric and duodenal ulcers in rats.
MedLine Citation:
PMID:  19602912     Owner:  NLM     Status:  MEDLINE    
The effect of centrally administered losartan, an AT(1) receptor antagonist, on gastric acid secretion and gastric cytoprotection was studied using different models of gastric ulcers, such as acetic acid-induced chronic gastric ulcers, pylorus ligation, ethanol-induced and stress-induced acute gastric ulcers and cysteamine hydrochloride-induced duodenal ulcer. Losartan was administered intracerebroventrically (i.c.v.) at 2 different doses (125 and 250 microg/kg). Both doses of losartan increased the healing of acetic acid-induced chronic gastric ulcers. In pylorus-ligated rats, a significant reduction in free acidity, total acidity and ulcer index was observed with high dose (250 microg/kg, i.c.v.), while low dose (125 microg/kg, i.c.v.) produced reduction only in free acidity and ulcer index. Both doses also produced a significant antiulcer effect in ethanol-induced and stress-induced gastric ulcers. Losartan also reduced ulcer area in cysteamine-induced duodenal ulcer. We conclude that AT(1) receptor antagonism in the brain increases healing of gastric ulcers and reduces gastric acid secretion and increases gastric mucin content.
Ankitkumar Harshadrai Merai; Mohammed Asad; V Satya Prasad
Publication Detail:
Type:  Journal Article     Date:  2009-07-15
Journal Detail:
Title:  Pharmacology     Volume:  84     ISSN:  1423-0313     ISO Abbreviation:  Pharmacology     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  93-8     Citation Subset:  IM    
Department of Pharmacology, Krupanidhi College of Pharmacy, Bangalore, India.
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MeSH Terms
Angiotensin II Type 1 Receptor Blockers / administration & dosage,  pharmacology*
Anti-Ulcer Agents / administration & dosage,  pharmacology
Brain / drug effects,  metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Duodenal Ulcer / drug therapy*,  physiopathology
Gastric Acid / secretion
Gastric Acidity Determination
Gastric Mucins / drug effects,  metabolism
Injections, Intraventricular
Losartan / administration & dosage,  pharmacology*
Rats, Wistar
Stomach Ulcer / drug therapy*,  physiopathology
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Anti-Ulcer Agents; 0/Gastric Mucins; 114798-26-4/Losartan

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