| Effect of centrally administered losartan on gastric and duodenal ulcers in rats. | |
| | |
MedLine Citation:
|
PMID: 19602912 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of centrally administered losartan, an AT(1) receptor antagonist, on gastric acid secretion and gastric cytoprotection was studied using different models of gastric ulcers, such as acetic acid-induced chronic gastric ulcers, pylorus ligation, ethanol-induced and stress-induced acute gastric ulcers and cysteamine hydrochloride-induced duodenal ulcer. Losartan was administered intracerebroventrically (i.c.v.) at 2 different doses (125 and 250 microg/kg). Both doses of losartan increased the healing of acetic acid-induced chronic gastric ulcers. In pylorus-ligated rats, a significant reduction in free acidity, total acidity and ulcer index was observed with high dose (250 microg/kg, i.c.v.), while low dose (125 microg/kg, i.c.v.) produced reduction only in free acidity and ulcer index. Both doses also produced a significant antiulcer effect in ethanol-induced and stress-induced gastric ulcers. Losartan also reduced ulcer area in cysteamine-induced duodenal ulcer. We conclude that AT(1) receptor antagonism in the brain increases healing of gastric ulcers and reduces gastric acid secretion and increases gastric mucin content. |
| | |
Authors:
|
Ankitkumar Harshadrai Merai; Mohammed Asad; V Satya Prasad |
Publication Detail:
|
Type: Journal Article Date: 2009-07-15 |
Journal Detail:
|
Title: Pharmacology Volume: 84 ISSN: 1423-0313 ISO Abbreviation: Pharmacology Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-08-21 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 93-8 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Krupanidhi College of Pharmacy, Bangalore, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II Type 1 Receptor Blockers
/
administration & dosage,
pharmacology* Animals Anti-Ulcer Agents / administration & dosage, pharmacology Brain / drug effects, metabolism Disease Models, Animal Dose-Response Relationship, Drug Duodenal Ulcer / drug therapy*, physiopathology Gastric Acid / secretion Gastric Acidity Determination Gastric Mucins / drug effects, metabolism Injections, Intraventricular Losartan / administration & dosage, pharmacology* Male Rats Rats, Wistar Stomach Ulcer / drug therapy*, physiopathology |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin II Type 1 Receptor Blockers; 0/Anti-Ulcer Agents; 0/Gastric Mucins; 114798-26-4/Losartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Elevated Erythropoietin in Vitreous of Patients with Rhegmatogenous Retinal Detachment and Prolifera...
Next Document: Effect of mometasone furoate on nasal congestion model in rats.