| Effect of centrally acting antihypertensive drugs on the renin-angiotensin system and vasopressin. | |
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MedLine Citation:
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PMID: 6084128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Such compounds as clonidine, guanabenz and guanfacine, which stimulate central alpha-adrenoceptors, reduce blood pressure predominantly by reducing sympathetic outflow. Notwithstanding, they also tend to reduce renin secretion, aldosterone, and even vasopressin levels. In some clinical settings, inactivation of the renin-angiotensin system may contribute to their antihypertensive effect. In addition, the absence of sodium retention, which appears to be a special feature of guanabenz, may also have a beneficial effect on blood pressure. In contrast, it is unlikely that a decrease in vasopressin secretion has any major influence on blood pressure. |
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Authors:
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B Waeber; J Nussberger; H R Brunner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 6 Suppl 5 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1984 |
Date Detail:
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Created Date: 1985-03-13 Completed Date: 1985-03-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S799-802 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology Animals Antihypertensive Agents / pharmacology* Blood Pressure / drug effects Clonidine / pharmacology Guanabenz / pharmacology Guanfacine Guanidines / pharmacology Humans Phenylacetates / pharmacology Renin / blood Renin-Angiotensin System / drug effects* Sodium / blood Vasopressins / blood* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Antihypertensive Agents; 0/Guanidines; 0/Phenylacetates; 11000-17-2/Vasopressins; 29110-47-2/Guanfacine; 4205-90-7/Clonidine; 5051-62-7/Guanabenz; 7440-23-5/Sodium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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