Document Detail


Effect of centrally acting antihypertensive drugs on the renin-angiotensin system and vasopressin.
MedLine Citation:
PMID:  6084128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Such compounds as clonidine, guanabenz and guanfacine, which stimulate central alpha-adrenoceptors, reduce blood pressure predominantly by reducing sympathetic outflow. Notwithstanding, they also tend to reduce renin secretion, aldosterone, and even vasopressin levels. In some clinical settings, inactivation of the renin-angiotensin system may contribute to their antihypertensive effect. In addition, the absence of sodium retention, which appears to be a special feature of guanabenz, may also have a beneficial effect on blood pressure. In contrast, it is unlikely that a decrease in vasopressin secretion has any major influence on blood pressure.
Authors:
B Waeber; J Nussberger; H R Brunner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  6 Suppl 5     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1984  
Date Detail:
Created Date:  1985-03-13     Completed Date:  1985-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S799-802     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology
Animals
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects
Clonidine / pharmacology
Guanabenz / pharmacology
Guanfacine
Guanidines / pharmacology
Humans
Phenylacetates / pharmacology
Renin / blood
Renin-Angiotensin System / drug effects*
Sodium / blood
Vasopressins / blood*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Antihypertensive Agents; 0/Guanidines; 0/Phenylacetates; 11000-17-2/Vasopressins; 29110-47-2/Guanfacine; 4205-90-7/Clonidine; 5051-62-7/Guanabenz; 7440-23-5/Sodium; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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