| Effect of a centralized prescription network on inappropriate prescriptions for opioid analgesics and benzodiazepines. | |
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MedLine Citation:
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PMID: 22949563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Opioid analgesics and benzodiazepines are often misused in clinical practice. We determined whether implementation of a centralized prescription network offering real-time access to patient-level data on filled prescriptions (PharmaNet) reduced the number of potentially inappropriate prescriptions for opioids and benzodiazepines. METHODS: We conducted a time series analysis using prescription records between Jan. 1, 1993, and Dec. 31, 1997, for residents of the province of British Columbia who were receiving social assistance or were 65 years or older. We calculated monthly percentages of filled prescriptions for an opioid or a benzodiazepine that were deemed inappropriate (those issued by a different physician and dispensed at a different pharmacy within 7 days after a filled prescription of at least 30 tablets of the same drug). RESULTS: Within 6 months after implementation of PharmaNet in July 1995, we observed a relative reduction in inappropriate filled prescriptions for opioids of 32.8% (95% confidence interval [CI] 31.0%-34.7%) among patients receiving social assistance; inappropriate filled prescriptions for benzodiazepines decreased by 48.6% (95% CI 43.2%-53.1%). Similar and statistically significant reductions were observed among residents 65 years or older. INTERPRETATION: The implementation of a centralized prescription network was associated with a dramatic reduction in inappropriate filled prescriptions for opioids and benzodiazepines. |
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Authors:
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Colin R Dormuth; Tarita A Miller; Anjie Huang; Muhammad M Mamdani; David N Juurlink; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2012-09-04 |
Journal Detail:
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Title: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Volume: 184 ISSN: 1488-2329 ISO Abbreviation: CMAJ Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-06 Completed Date: 2013-01-16 Revised Date: 2013-03-21 |
Medline Journal Info:
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Nlm Unique ID: 9711805 Medline TA: CMAJ Country: Canada |
Other Details:
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Languages: eng Pagination: E852-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, University of British Columbia, Vancouver, BC, Canada. colin.dormuth@ti.ubc.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analgesics, Opioid / therapeutic use* Benzodiazepines / therapeutic use* British Columbia Confidence Intervals Cross-Sectional Studies Databases, Factual Drug Prescriptions / standards*, statistics & numerical data Drug Therapy, Computer-Assisted* Drug Utilization / statistics & numerical data, trends Drug and Narcotic Control / organization & administration Electronic Prescribing Female Humans Inappropriate Prescribing / prevention & control*, statistics & numerical data Incidence Information Services / organization & administration* Male Middle Aged Organizational Innovation Pharmaceutical Services / organization & administration* Quality Control Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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ETG-92247//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 12794-10-4/Benzodiazepines |
| Investigator | |
Investigator/Affiliation:
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David N Juurlink / ; Colin R Dormuth / ; Chelsea Hellings / ; Anita L Kozyrskyj / ; Muhammad M Mamdani / ; Yola Moride / ; J Michael Paterson / ; Colette Raymond / ; Robyn Tamblyn / |
| Comments/Corrections | |
Comment In:
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CMAJ. 2012 Nov 6;184(16):1767-8
[PMID:
23008488
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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