Document Detail

Effect of central venous pressure on brain tissue pressure and brain volume.
MedLine Citation:
PMID:  932805     Owner:  NLM     Status:  MEDLINE    
In cats, brain tissue pressure (BTP) was measured by the wick-catheter method. The BTP was positive, but lower than cerebrospinal fluid pressure. Elevation on central venous pressure led only to a transient proportional increase of BTP. When the calvaria and dura of one hemisphere were removed, the rise of BTP was even less. Water content of the brain was normal in either case, even after prolonged venous hypertension. Venous hypertension led in all cases to a marked increase of the brain volume which was caused by vessel dilatation. In brain edema, produced by rinsing the brain surface with ouabain and concentrated saline, BTP was increased permanently by venous hypertension. The water content of the brain was much greater than normal. From these results it was concluded that congestive edema does not occur in the brain unless the tissue is damaged. However, venous hypertension does cause brain swelling.
J Cuypers; F Matakas; S J Potolicchio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  45     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-09-02     Completed Date:  1976-09-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Brain / physiology*
Brain Edema / physiopathology
Central Venous Pressure*
Cerebral Hemorrhage / etiology
Extracellular Space / physiology
Intracranial Pressure*

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