| Effect of central thyrotropin-releasing hormone on pancreatic blood flow in rats. | |
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MedLine Citation:
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PMID: 15256274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Central neuropeptides play a role in physiological regulation through the autonomic nervous system. Thyrotropin-releasing hormone (TRH) is a neuropeptide distributed throughout the central nervous system and acts as a neurotransmitter to regulate gastric and hepatic functions through vagal-cholinergic pathways. In this study, the central effect of TRH on pancreatic blood flow was investigated in urethane-anesthetized rats. Pancreatic blood flow was determined by laser Doppler flowmetery. After measurement of basal blood flow, a stable TRH analog, RX 77368 (1-50 ng) or saline was injected intracisternally. Pancreatic blood flow was observed for 120 min thereafter. In some experiments, pretreatment with atropine methyl nitrate (0.15 mg/kg, i.p.), NG-nitro-L-arginine-methyl ester (10 mg/kg, i.v.), or 6-hydroxydopamine (6-OHDA;180 mg/kg, i.p.), or subdiaphragmatic vagotomy was performed. Intracisternal injection of TRH analog dose-dependently increased pancreatic blood flow with a peak response occurring 30 min after injection. The stimulatory effect of TRH analog on pancreatic blood flow was blocked by vagotomy, atropine, and NG-nitro-L-arginine-methyl ester, but not by 6-hydroxydopamine. Intravenous administration of the TRH analog did not influence pancreatic blood flow in the same animal model. These results indicate that TRH acts in the central nervous system to stimulate pancreatic blood flow through vagal-cholinergic and nitric oxide-dependent pathways. |
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Authors:
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Manabu Goto; Masashi Yoneda; Kimihide Nakamura; Akira Terano; Masakazu Haneda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Regulatory peptides Volume: 121 ISSN: 0167-0115 ISO Abbreviation: Regul. Pept. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-07-16 Completed Date: 2005-03-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: Netherlands |
Other Details:
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Languages: eng Pagination: 57-63 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Elsevier B.V. |
Affiliation:
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Second Department of Medicine, Asahikawa Medical College, Asahikawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Blood Pressure / drug effects Male NG-Nitroarginine Methyl Ester / pharmacology Oxidopamine / pharmacology Pancreas / blood supply*, drug effects* Rats Regional Blood Flow / drug effects* Thyrotropin-Releasing Hormone / administration & dosage, analogs & derivatives, pharmacology* Vagotomy |
| Chemical | |
Reg. No./Substance:
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1199-18-4/Oxidopamine; 24305-27-9/Thyrotropin-Releasing Hormone; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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