| Effect of catheter-based transendocardial delivery of stromal cell-derived factor 1alpha on left ventricular function and perfusion in a porcine model of myocardial infarction. | |
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MedLine Citation:
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PMID: 16382289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Myocardial regeneration after myocardial infarction can occur via stem cell recruitment. Stromal cell-derived factor 1alpha (SDF-1alpha) has been shown to be critical for stem cell homing to injured tissue. METHODS: Myocardial infarction was induced in pigs via microembolization of the distal left anterior descending artery. Two weeks after myocardial infarction animals underwent catheter-based transendocardial injection of SDF-1alpha into the periinfarct myocardium (18 injections, 5 ìg per injection) (n = 12) or sham-intervention (n = 8). Tc99m sestamibi single-photon emission computed tomography (SPECT) and electromechanical mapping (EMM) of the left ventricle were performed two and seven weeks after myocardial infarction. RESULTS: Infarct size by tetrazolium staining was similar in both groups (8.9 +/-1.2% of left ventricle vs. 8.9 +/- 2.6%). Vessel density in the periinfarct area was significantly higher in SDF-1alpha treated animals than in controls (349 +/- 17/mm2 vs. 276 +/- 21/mm2, p < 0.05). Myocardial perfusion (SPECT) did not change in either group. Ejection fraction and stroke volume (EMM) decreased in SDF-1alpha animals and increased in controls (difference between groups p = 0.05 for ejection fraction and p < 0.05 for stroke volume). Linear local shortening (EMM) did not change in controls (11.4 +/- 1.3% to 11.5 +/- 0.5%) but decreased significantly in SDF-1alpha treated animals (12.1 +/- 0.9% to 8.4 +/- 0.9%, p < 0.05, p < 0.05 for difference between groups). SDF-1 delivery was associated with a substantial loss of collagen in the periinfarct area (32+/-5% vs. 61+/-6% in control animals, p < 0.005). CONCLUSION: A strategy to augment stem cell homing by catheter-based transendocardial delivery of SDF-1alpha in experimental myocardial infarction increases periinfarct vessel density, fails to improve myocardial perfusion, is associated with loss of collagen in the periinfarct area and impairs left ventricular function. |
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Authors:
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Karl-Christian Koch; Wolfgang M Schaefer; Elisa A Liehn; Christos Rammos; Dominik Mueller; Joerg Schroeder; Tarek Dimassi; Thaddaeus Stopinski; Christian Weber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Basic research in cardiology Volume: 101 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-29 Completed Date: 2006-06-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 69-77 Citation Subset: IM |
Affiliation:
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Department of Cardiology, RWTH Aachen University, Pauwelstrasse 30, 52074 Aachen, Germany. kckoch@ukaachen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catheterization, Peripheral Chemokine CXCL12 Chemokines, CXC / administration & dosage* Collagen Coronary Vessels / drug effects Female Infusions, Intra-Arterial Infusions, Intralesional Myocardial Infarction / drug therapy*, pathology Swine Ventricular Function, Left / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CXCL12; 0/Chemokines, CXC; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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