Document Detail

Effect of catecholaminergic drugs on quinolinate- and kynurenine-induced seizures in mice.
MedLine Citation:
PMID:  2144973     Owner:  NLM     Status:  MEDLINE    
Administration of reserpine, trifluperidol, chlorpromazine, haloperidol, spiroperidol, and thioproperazine to adult mice shortened the latency and increased the number of animals with clonic seizures induced by 1-kynurenine sulfate or its metabolite quinolinic acid. Haloperidol dose-dependently intensified kynurenine-induced seizures and did not alter pentylenetetrazole seizures. Dopamine abolished the effect of haloperidol while serotonin was ineffective. Pretreatment with 6-hydroxydopamine potentiated kynurenine-induced seizures, but not quinolinic acid-induced seizures. The seizure thresholds of kynurenine and quinolinic acid were not affected by pretreatments with yohimbine, clonidine, piperoxan, phentolamine and tricyclic antidepressants. Apomorphine and amphetamine (i.p.), noradrenaline and adrenaline (i.c.v.) possess anticonvulsant action against kynurenine and not against quinolinic acid. The data obtained suggest a similarity of kynurenine and known convulsants in the involvement of the catecholaminergic processes in their convulsant action. Quinolinic acid markedly differs from kynurenine in its mechanism of action as indicated by their interactions with numerous endogenous substances.
I P Lapin; I V Ryzov
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of neural transmission. General section     Volume:  82     ISSN:  -     ISO Abbreviation:  J. Neural Transm. Gen. Sect.     Publication Date:  1990  
Date Detail:
Created Date:  1990-11-01     Completed Date:  1990-11-01     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9002201     Medline TA:  J Neural Transm Gen Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  55-65     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / pharmacology
Catecholamines / pharmacology*
Dopamine / pharmacology
Mice, Inbred Strains
Quinolinic Acid
Quinolinic Acids*
Seizures / chemically induced,  metabolism*
Sympathomimetics / pharmacology
Reg. No./Substance:
0/Anticonvulsants; 0/Catecholamines; 0/Convulsants; 0/Quinolinic Acids; 0/Sympathomimetics; 343-65-7/Kynurenine; F6F0HK1URN/Quinolinic Acid; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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