Document Detail


Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides.
MedLine Citation:
PMID:  22806230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Hofmann-type rearrangement of aromatic and aliphatic imides using KBr as the catalyst proceeded to provide aromatic and aliphatic amino acid derivatives. We have also developed a new synthetic route to gabapentin with this method.
Authors:
Katsuhiko Moriyama; Kazuma Ishida; Hideo Togo
Publication Detail:
Type:  Journal Article     Date:  2012-07-18
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  48     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-31     Completed Date:  2012-11-29     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  8574-6     Citation Subset:  IM    
Affiliation:
Graduate School of Science, Chiba University, Chiba 263-8522, Japan. moriyama@faculty.chiba-u.jp
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MeSH Terms
Descriptor/Qualifier:
Amines / chemical synthesis,  chemistry
Bromides / chemistry*
Catalysis
Cyclohexanecarboxylic Acids / chemical synthesis,  chemistry
Imides / chemistry*
Metals, Alkali / chemistry*
Oxidation-Reduction
gamma-Aminobutyric Acid / chemical synthesis,  chemistry
Chemical
Reg. No./Substance:
0/Amines; 0/Bromides; 0/Cyclohexanecarboxylic Acids; 0/Imides; 0/Metals, Alkali; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin

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