Document Detail


Effect of castration on renin-angiotensin system of hypertensive rats submitted to chronic hypobaric hypoxia (simulated altitude: 4400 m).
MedLine Citation:
PMID:  9439779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to provide an overview of the role of circulating gonadal steroids on the adaptive changes of the renin-angiotensin system to chronic hypobaric hypoxia (CHH: 4400 m simulated altitude in an hypobaric chamber) and the development of experimental hypertension by bilateral renal ischemia. In order to fulfill this goal, blood pressure (BP), plasma renin activity (PRA) and plasma angiotensinogen concentration (PAoC) as well as haematocrit (Htc) and body weight (BW) of intact and post-puberal castrated normotensive (Nt) and hypertensive (Ht) rats of both sexes were studied following an experimental design similar to that of previous works. Post-puberal castration decreased BP of Nt and Ht rats subjected to CHH. Sexual dimorphism in BP, PRA and PAoC was maintained while that in haematocrit disappeared after castration. Results suggest that circulating sexual steroid hormones are involved in the response of the renin-angiotensin system to the experimental conditions of environmental reduced O2 partial pressure.
Authors:
I Martín; N Basso; F Aguirre; M I Sarchi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of physiology and biochemistry     Volume:  105     ISSN:  1381-3455     ISO Abbreviation:  Arch. Physiol. Biochem.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-02-18     Completed Date:  1998-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9510153     Medline TA:  Arch Physiol Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  429-34     Citation Subset:  IM; S    
Affiliation:
Hospital de Clínicas José de San Martín, Departamento de Docencia e Investigación, Facultad de Medicina, Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology
Altitude
Angiotensinogen / blood
Animals
Anoxia / physiopathology*
Blood Pressure / physiology
Body Weight / physiology
Female
Gonadal Steroid Hormones / physiology
Hematocrit
Hypertension, Renovascular / physiopathology*
Male
Orchiectomy
Ovariectomy
Rats
Rats, Wistar
Renin / blood
Renin-Angiotensin System / physiology*
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones; 11002-13-4/Angiotensinogen; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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