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Effect of carvedilol on silent anthracycline-induced cardiotoxicity assessed by strain imaging: A prospective randomized controlled study with 6-month follow-up.
MedLine Citation:
PMID:  24142687     Owner:  NLM     Status:  Publisher    
BACKGROUND: The use of Antracycline (ANT) in breast cancer has been associated with adverse cardiac events. Two-dimensional strain imaging (SI) can provide a more sensitive measure of altered left ventricle ( LV) systolic function. We aimed to evaluate the preventive effect of carvedilol administration assessed by SI in a patient with breast cancer treated with ANT.
METHODS: Patients receiving ANT were randomly assigned to the carvedilol- or placebo-receiving group. Each received an echocardiographic examination with conventional two-dimensional echocardiography (2D), pulsed tissue Doppler, and 2D SI prior to and 6 months post ANT treatment.
RESULTS: During the 6-month follow-up period there were no patient deaths or interrupted chemotherapy (CT) treatments due to doxorubicin-induced cardiotoxicity. Both left ventricular ejection fraction (LVEF) and fractional shortening (FS) were within normal limits for all patients before and after ANT therapy. EF, FS and LV dimensions were measured using M mode echocardiography and found to be similar in both groups before and after ANT therapy. The mean EF, FS, and LV echocardiograph baseline and control dimensions were similar in both groups after 6 months. Though baseline SI parameters were similar between the groups, there was a significant decrease in LV basal septal and basal lateral peak systolic strain in the control group compared to the carvedilol group.
CONCLUSIONS: These results indicate that carvedilol has a protective effect against the cardiotoxicity induced by ANT.
Ali Elitok; Fahrettin Oz; Ahmet Y Cizgici; Leyla Kilic; Rumeysa Ciftci; Fatma Sen; Zehra Bugra; Fehmi Mercanoglu; Aytac Oncul; Huseyin Oflaz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-21
Journal Detail:
Title:  Cardiology journal     Volume:  -     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Medical doctor. Department of Cardiology, School of Istanbul medicine, Istanbul University.
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