Document Detail

Effect of carvedilol on portal pressure estimated by hepatic vein Doppler ultrasound waveform and damping index in cirrhotic patients.
MedLine Citation:
PMID:  20810049     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effect of Carvedilol in reducing portal pressure estimated non-invasively by studying Doppler ultrasound waveforms (DUS) and hepatic vein Damping Index (DI).
STUDY DESIGN: Quasi-experimental study.
PLACE AND DURATION OF STUDY: Department of Medical ICU in collaboration with Department of Radiology, JPMC, over a period of 6 months (June 1st to 30th November, 2008).
METHODOLOGY: Of the enrolled 65 patients, 47 patients (33 males and 14 females) completed the study. The mean age was 47.4 years. Cirrhotic patients of Hepatitis B, C, D (delta), B and C combined, B and D combined with varying degrees of portal hypertension were included in the study. Cirrhotic patients with bronchial asthma, congestive heart failure, Insulin dependent Diabetes, portal vein thrombosis and hepatorenal syndrome were excluded from the study. The patients were examined by color flow Doppler of the right hepatic vein before and after administration of Carvedilol. Their waveforms and Damping Index (DI) were recorded and compared by Wilcoxon signed ranks test through SPSS version 12.0. Responders were described as those showing a positive change in wave forms or a decrese of 0.10 or more in DI.
RESULTS: Of the 47 patients, 30 (63%) showed a positive response and 10 (21%) showed no favorable response to Carvedilol, while 7 (14%) patients showed deterioration. The mean DI on DUS dropped from 0.62 to 0.41 in responders after treatment, while in the non-responders it ranged between 0.42 and 0.57.
CONCLUSION: Ultrasonography Carvedilol reduced portal pressure of cirrhotic patients, as measured indirectly by the damping index of hepatic waveform by Doppler.
Qurban Hussain; Aly Haider Badruddin; M Azhar Chaudhry; Fayyaz Ahmad; Amanullah Abbasi
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP     Volume:  20     ISSN:  1022-386X     ISO Abbreviation:  J Coll Physicians Surg Pak     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-11-02     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9606447     Medline TA:  J Coll Physicians Surg Pak     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  586-9     Citation Subset:  IM    
Medical ICU, Jinnah Postgraduate Medical Centre, Karachi.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Blood Flow Velocity
Carbazoles / therapeutic use*
Hepatic Veins / ultrasonography*
Hypertension, Portal / etiology,  physiopathology*,  ultrasonography
Liver Cirrhosis / complications,  physiopathology*,  ultrasonography
Middle Aged
Portal Pressure / drug effects*
Propanolamines / therapeutic use*
Ultrasonography, Doppler, Color
Ultrasonography, Doppler, Duplex*
Young Adult
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol

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