Document Detail

Effect of carvedilol on atrioventricular conduction in the ischemic heart.
MedLine Citation:
PMID:  11165226     Owner:  NLM     Status:  MEDLINE    
We compared the effects of carvedilol on atrial-His and His-ventricular conduction with those of propranolol in isolated rat hearts. Hearts were perfused retrograde, and atrial-His and His-ventricular intervals were measured. The effective doses that increased conduction times by 25% were 10(-6) M for atrial-His and 3x10(-6) M for His-ventricular for propranolol, and 8x10(-8) M for atrial-His and 10(-8) M for His-ventricular for carvedilol. Prazosin did not affect the atrial-His and His-ventricular intervals. After ischemia-reperfusion, atrial-His and His-ventricular intervals increased to a greater extent with 10(-6) M carvedilol. To determine the direct membrane effect, we examined the transmembrane action potential in guinea pig papillary muscle. Both drugs decreased the maximum upstroke velocity equally. Our data indicate that carvedilol had a greater effect on atrioventricular conduction in the setting of ischemia-reperfusion than did propranolol. This effect of carvedilol was not due to its alpha-adrenoceptor blocking property or to a direct membrane effect.
T Horio; S Ito; M Aoyama; Y Takeda; H Suzumura; K Nakata; Y Yamada; S Suzuki; T Fukutomi; M Itoh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  412     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2002-02-21     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  145-53     Citation Subset:  IM    
The First Department of Internal Medicine, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Aichi-ken, Nagoya, Japan.
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MeSH Terms
Action Potentials / drug effects,  physiology
Adrenergic alpha-Antagonists / pharmacology,  therapeutic use
Adrenergic beta-Antagonists / pharmacology*,  therapeutic use
Bundle of His / drug effects*,  physiology
Carbazoles / pharmacology*,  therapeutic use
Guinea Pigs
Myocardial Ischemia / drug therapy
Papillary Muscles / drug effects,  physiology
Prazosin / pharmacology,  therapeutic use
Propanolamines / pharmacology*,  therapeutic use
Propranolol / pharmacology*,  therapeutic use
Rats, Sprague-Dawley
Reperfusion Injury / drug therapy
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol; 19216-56-9/Prazosin; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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