| Effect of carvedilol on atrioventricular conduction in the ischemic heart. | |
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MedLine Citation:
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PMID: 11165226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared the effects of carvedilol on atrial-His and His-ventricular conduction with those of propranolol in isolated rat hearts. Hearts were perfused retrograde, and atrial-His and His-ventricular intervals were measured. The effective doses that increased conduction times by 25% were 10(-6) M for atrial-His and 3x10(-6) M for His-ventricular for propranolol, and 8x10(-8) M for atrial-His and 10(-8) M for His-ventricular for carvedilol. Prazosin did not affect the atrial-His and His-ventricular intervals. After ischemia-reperfusion, atrial-His and His-ventricular intervals increased to a greater extent with 10(-6) M carvedilol. To determine the direct membrane effect, we examined the transmembrane action potential in guinea pig papillary muscle. Both drugs decreased the maximum upstroke velocity equally. Our data indicate that carvedilol had a greater effect on atrioventricular conduction in the setting of ischemia-reperfusion than did propranolol. This effect of carvedilol was not due to its alpha-adrenoceptor blocking property or to a direct membrane effect. |
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Authors:
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T Horio; S Ito; M Aoyama; Y Takeda; H Suzumura; K Nakata; Y Yamada; S Suzuki; T Fukutomi; M Itoh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 412 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2002-02-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 145-53 Citation Subset: IM |
Affiliation:
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The First Department of Internal Medicine, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Aichi-ken, Nagoya, Japan. horioto@rcs.tokai.west.ntt.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects,
physiology Adrenergic alpha-Antagonists / pharmacology, therapeutic use Adrenergic beta-Antagonists / pharmacology*, therapeutic use Animals Bundle of His / drug effects*, physiology Carbazoles / pharmacology*, therapeutic use Guinea Pigs Male Myocardial Ischemia / drug therapy Papillary Muscles / drug effects, physiology Prazosin / pharmacology, therapeutic use Propanolamines / pharmacology*, therapeutic use Propranolol / pharmacology*, therapeutic use Rats Rats, Sprague-Dawley Reperfusion Injury / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 19216-56-9/Prazosin; 525-66-6/Propranolol; 72956-09-3/carvedilol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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