Document Detail


Effect of carvedilol on atrial remodeling in canine model of atrial fibrillation.
MedLine Citation:
PMID:  24649422     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
AIMS: We evaluated the effect of carvedilol, a beta-blocker with anti-oxidative action, against the atrial fibrillation (AF) inducibility, the development of atrial remodeling and the oxidative stress markers in a canine AF model.
METHODS AND RESULTS: AF model was produced by performing 6-week rapid atrial stimulation in 15 dogs. The animals were divided into the following three groups: (I) pacing + carvedilol group (n=5); (II) pacing control group (n=5); and (III) non-pacing group (n=5). AF inducibility was gradually increased along the time course in the pacing control group. In the pacing + carvedilol group, the AF inducibility was suppressed especially in the latter phase of protocol in comparison with the pacing control group. Although carvedilol has beta-blocking effect, pacing control and pacing + carvedilol groups did not exhibit difference in the heart rate (177±13 vs. 155±13 bpm, P=0.08). On 8-hydroxy-2'-deoxyguanosine (8-OHdG), dihydroethidium and dichlorodihydrofluorescein diacetate staining, enhanced oxidative stress was observed in the atrial tissue in the pacing control, but not in the pacing + carvedilol group.
CONCLUSIONS: Carvedilol suppressed AF inducibility and oxidative stress in the canine AF model.
Authors:
Jun Kishihara; Shinichi Niwano; Hiroe Niwano; Yuya Aoyama; Akira Satoh; Jun Oikawa; Michiro Kiryu; Hidehira Fukaya; Yoshihiko Masaki; Hideaki Tamaki; Tohru Izumi; Junya Ako
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular diagnosis and therapy     Volume:  4     ISSN:  2223-3652     ISO Abbreviation:  Cardiovasc Diagn Ther     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-03-20     Completed Date:  2014-03-20     Revised Date:  2014-03-24    
Medline Journal Info:
Nlm Unique ID:  101601613     Medline TA:  Cardiovasc Diagn Ther     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  28-35     Citation Subset:  -    
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