Document Detail

Effect of carnitine on size limitation of experimental myocardial infarct.
MedLine Citation:
PMID:  2264986     Owner:  NLM     Status:  MEDLINE    
To elucidate 1-carnitine chloride effects ischemic myocardium for the possibility of a salvage of risk zone around necrosis in myocardial infarcts of dogs, a quantitative evaluation of the extent of myocardial infarcts was done by size detection with use of monastral blue and tissue dehydrogenase histochemistry at 20 hours after coronary ligation. The results show that the ratio of unsalvaged infarct zone to occluded coronary bed is 85.3 +/- 2.9% in the control group, while it is 53.2 +/- 3.6% in the 1-carnitine administered (1 C) group. The difference between these ratios is statistically significant (p less than 0.01). The results also indicate significantly lower serum CPK concentration. Therefore, carnitine may play a role in preventing a size extention of infarcts through improving an altered lipid metabolism, particularly a fatty acid metabolism, of myocardial cells in the risk zone.
K Ura; Y Hironaka; I Sakurai
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of cardiovascular pathology     Volume:  3     ISSN:  0887-8005     ISO Abbreviation:  Am J Cardiovasc Pathol     Publication Date:  1990  
Date Detail:
Created Date:  1991-02-13     Completed Date:  1991-02-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702438     Medline TA:  Am J Cardiovasc Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  131-42     Citation Subset:  IM    
Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Carnitine / therapeutic use*
Creatine Kinase / blood
Fatty Acids, Nonesterified / blood
Microscopy, Electron
Myocardial Infarction / blood,  drug therapy*,  pathology
Myocardium / pathology*
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 541-15-1/Carnitine; EC Kinase

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