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Effect of cardiac resynchronization therapy on left atrial reverse remodeling: Role of echocardiographic AV delay optimization.
MedLine Citation:
PMID:  22560916     Owner:  NLM     Status:  Publisher    
BACKGROUND/OBJECTIVES: Cardiac resynchronization therapy (CRT) improves left ventricular (LV) function in patients with advanced heart failure (HF) and there are some evidences about beneficial effects also on left atrial (LA) dimension and function. The contribution of atrioventricular delay (AVD) optimization on LA changes has not been evaluated. The purpose of the present study was to further investigate the effect of CRT on LA reverse remodelling and to evaluate the contribution of AVD optimization. METHODS AND RESULTS: From the Cardiology Department of Piacenza Hospital and Modena University Hospital fifty one patients with refractory systolic HF and left bundle branch block were prospectively enrolled before CRT implantation. Patients were 1:1 randomized to either an optimized AVD (AV Opt group) determined by continuous wave Doppler aortic velocity-time integral (VTI) or an empiric AVD of 110ms (AV Fixed group). Optimal AVD was defined as the AVD that yielded the largest aortic VTI at one of eight tested AV intervals (between 60 and 200ms). LA volumes and emptying fractions were assessed by two-dimensional echocardiography at baseline and 6months after CRT. At 6-month follow-up, CRT induced LA reverse remodeling in the whole population (maximal LA volume: 55.8±16.4ml/m² vs 50.3±18.9ml/m², p=0.006; pre-systolic LA volume: 47.0±15.2ml/m² vs 41.4±17.4ml/m², p=0.003; post-systolic LA volume: 36.4±15.0ml/m² vs 30.3±18.0ml/m(2), p=0.001); nevertheless, no substantial difference was observed about LA structural and functional remodeling between both AV Opt group and AV Fixed group. CONCLUSION: CRT induces LA reverse remodeling that appears independent from AVD optimization.
Alessandro Malagoli; Luca Rossi; Francesco Franchi; Massimo Francesco Piepoli; Vincenzo Malavasi; Edoardo Casali; Maria Grazia Modena; Giovanni Quinto Villani
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-4
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Department of Cardiology, "Guglielmo da Saliceto" Hospital, Piacenza, Via Taverna 49, 29100 Piacenza, Italy.
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