| Effect of cardiac output on mitral valve area in patients with mitral stenosis: validation and pitfalls of the pressure half-time method. | |
| | |
MedLine Citation:
|
PMID: 11206768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND AIM OF THE STUDY: The non-invasive evaluation of mitral valve area is often used in the assessment of patients with mitral stenosis. The pressure half-time method is commonly used to calculate valve area, but is inaccurate in many clinical scenarios. We sought to quantify the effects of changing cardiac output on the accuracy of mitral valve area determination. METHODS: Thirteen patients with mitral stenosis underwent routine stress echocardiography with resting and peak exercise results compared. A previously described and clinically validated mathematical model of the cardiovascular system was used to validate the clinical results. Seven different loading conditions for each of four different stenotic valve areas were modeled. RESULTS: In patients, with increasing cardiac output, pressure half-time decreased (-30.6+/-35.3 ms/l/min) and calculated valve area increased by 0.25+/-0.30 cm2/l/min. By continuity, it appeared that approximately half of this increase was due to actual valve orifice stretching, the remainder reflecting fundamental changes in the relationship between half-time and valve area. Mathematical modeling resulted in similar changes in pressure half-time and calculated valve area (0.06 to 0.12 cm2/l/min, p = 0.20 versus clinical results). CONCLUSION: Changes in cardiac output result in predictable changes in pressure half-time, and should be considered when performing serial examinations in patients with mitral stenosis. |
| | |
Authors:
|
M S Firstenberg; D L Prior; N L Greenberg; S Wahi; A Pasquet; M J Garcia; J D Thomas |
Related Documents
:
|
8923988 - Experimental analysis of fluid mechanical energy losses in aortic valve stenosis: impor... 19727008 - Synergistic effect of mitral expression of tissue inhibitor of metalloproteinase-2 with... 16153508 - Pulmonary regurgitation end-diastolic gradient is a doppler marker of cardiac status: d... 10367468 - Staffieri tracheo-oesophageal prosthesis for voice rehabilitation after laryngectomy: a... 7491088 - Vascular alpha-1 adrenergic receptor subtypes in the regulation of arterial pressure. 10941618 - Trend of blood pressure in north indian children. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of heart valve disease Volume: 10 ISSN: 0966-8519 ISO Abbreviation: J. Heart Valve Dis. Publication Date: 2001 Jan |
Date Detail:
|
Created Date: 2001-02-05 Completed Date: 2001-04-26 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9312096 Medline TA: J Heart Valve Dis Country: England |
Other Details:
|
Languages: eng Pagination: 49-56 Citation Subset: IM |
Affiliation:
|
Cardiovascular Imaging Center in the Department of Cardiology, The Cleveland Clinic Foundation, Ohio 44195, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Pressure / physiology* Cardiac Output / physiology* Computer Simulation Diastole / physiology Echocardiography* Echocardiography, Doppler Exercise Test* Female Heart Rate / physiology Humans Male Middle Aged Mitral Valve / physiopathology, ultrasonography* Mitral Valve Stenosis / physiopathology, ultrasonography* Models, Theoretical Stroke Volume / physiology Systole / physiology Ventricular Function, Left / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
1R01HL56688-01A1/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Left ventricular remodeling after pulmonary autograft replacement of the aortic valve (Ross operatio...
Next Document: Relationship between papillary muscle size and benefit to cardiac function in mitral valve replaceme...