Document Detail

Effect of cardiac function on aortic peak time and peak enhancement during coronary CT angiography.
MedLine Citation:
PMID:  19442467     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine the manner in which cardiac function affects the magnitude and timing of aortic contrast enhancement during coronary CT angiography (CTA).
MATERIALS AND METHODS: Twenty-nine patients (21 men, 8 women; mean age, 64.4+/-13.4 years; mean weight, 59.4+/-10.3 kg) underwent measurement of cardiac output within 2 weeks of coronary CTA. The cardiac output of each patient was measured by the thermodilution technique and the cardiac index was calculated from the body surface area. During coronary CTA, attenuation of the descending aorta was measured at the workstation every 3s. The aortic peak time (APT) and aortic peak enhancement (APE) of each patient were calculated. Pearson's correlation coefficient analysis was used to investigate the relationships between the cardiac output or cardiac index and APT or APE. Furthermore, the relationship between patient factors or parameters on test bolus injection and APT or APE was also evaluated.
RESULTS: The range of cardiac output, cardiac index, APT, and APE was 1.55-10.46 L/min (mean: 4.77+/-2.13), 1.11-5.30 L/(min-m(2)) (mean: 3.28+/-1.08), 25-51 s (mean: 38.3+/-7.5), and 273.1-598.1 HU (mean: 390.4+/-72.1), respectively. With an increase in the cardiac index, both APT (r=-0.698, p<0.0001) and APE (r=-0.573, p=0.0009) decreased. There were significant correlations between the patient body weight and APT and APE with the test bolus injection, and with APT and APE during coronary CTA.
CONCLUSION: The APT and APE during coronary CTA are closely related to cardiac function.
Shuji Sakai; Hidetake Yabuuchi; Akiko Chishaki; Takashi Okafuji; Yoshio Matsuo; Takeshi Kamitani; Taro Setoguchi; Hiroshi Honda
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Publication Detail:
Type:  Journal Article     Date:  2009-05-13
Journal Detail:
Title:  European journal of radiology     Volume:  75     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-13     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
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MeSH Terms
Aged, 80 and over
Aorta, Thoracic / radiography*
Body Weight
Cardiac Output*
Contrast Media*
Coronary Angiography*
Iohexol / diagnostic use*
Middle Aged
Myocardial Ischemia / radiography
Stroke Volume
Tomography, X-Ray Computed*
Reg. No./Substance:
0/Contrast Media; 66108-95-0/Iohexol

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