Document Detail

Effect of carbon source on pyrimidine biosynthesis in Pseudomonas oryzihabitans.
MedLine Citation:
PMID:  20473969     Owner:  NLM     Status:  MEDLINE    
The effect of carbon source on the regulation of pyrimidine biosynthesis in the opportunistic human pathogen Pseudomonas oryzihabitans was studied at the level of enzyme synthesis. Although pyrimidine supplementation of glucose-grown Ps. oryzihabitans cells produced a slight but statistically significant effect on the de novo pyrimidine biosynthetic pathway enzyme activities, catabolite repression of the enzyme activities by glucose appeared to be occurring. Pyrimidine limitation experiments undertaken using an orotidine 5'-monophosphate decarboxylase mutant strain grown on glucose indicated that repression of enzyme synthesis by pyrimidines was occurring. Following pyrimidine limitation of the mutant strain cells, dihydroorotase and dihydroorotate dehydrogenase activities were found to about double while aspartate transcarbamoylase and orotate phosphoribosyltransferase activities were slightly elevated compared to their activities in the mutant strain cells grown on excess uracil.
Thomas P West
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of basic microbiology     Volume:  50     ISSN:  1521-4028     ISO Abbreviation:  J. Basic Microbiol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503885     Medline TA:  J Basic Microbiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  397-400     Citation Subset:  IM    
Copyright Information:
Copyright 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA.
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MeSH Terms
Aspartate Carbamoyltransferase / metabolism
Carbon / metabolism*
Culture Media*
Glucose / metabolism
Orotate Phosphoribosyltransferase / metabolism
Orotidine-5'-Phosphate Decarboxylase / metabolism
Pseudomonas / enzymology*
Pyrimidines / biosynthesis*
Reg. No./Substance:
0/Culture Media; 0/Pyrimidines; 50-99-7/Glucose; 7440-44-0/Carbon; EC Carbamoyltransferase; EC Phosphoribosyltransferase; EC'-Phosphate Decarboxylase

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