Document Detail

Effect of carbon nanotube coating of aligned nanofibrous polymer scaffolds on the neurite outgrowth of PC-12 cells.
MedLine Citation:
PMID:  21332449     Owner:  NLM     Status:  MEDLINE    
Neurite outgrowth from endogenous or transplanted cells is important for neural regeneration following nerve tissue injury. Modified substrates often provide better environments for cell adhesion and neurite outgrowth. This study was conducted to determine if MWCNT (multiwalled carbon nanotube)-coated electrospun PLCL [poly (l-lactic acid-co-3-caprolactone)] nanofibres improved the neurite outgrowth of PC-12 cells. To accomplish this, two groups, PC-12 cells in either uncoated PLCL scaffolds or MWCNT-coated PLCL scaffolds were cultured for 9 days. MWCNT-coated PLCL scaffolds showed improved adhesion, proliferation and neurite outgrowth of PC-12 cells. These findings suggest that MWCNT-coated nanofibrous scaffolds may be an attractive platform for cell transplantation application in neural tissue engineering.
Guang-Zhen Jin; Meeju Kim; Ueon Sang Shin; Hae-Won Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biology international     Volume:  35     ISSN:  1095-8355     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-20     Completed Date:  2011-10-03     Revised Date:  2012-08-02    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  741-5     Citation Subset:  IM    
Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, South Korea.
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MeSH Terms
Cell Differentiation / drug effects
Cell Proliferation / drug effects
Coated Materials, Biocompatible / chemical synthesis*,  pharmacology
Hexanoic Acids / chemistry*
Lactic Acid / chemistry
Lactones / chemistry*
Microscopy, Electron, Scanning
Nanofibers / chemistry*
Nanotubes, Carbon / chemistry*
Nerve Regeneration*
Neurites / drug effects*
PC12 Cells
Polymers / chemical synthesis,  pharmacology
Tissue Engineering / methods*
Tissue Scaffolds
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Hexanoic Acids; 0/Lactones; 0/Nanotubes, Carbon; 0/Polymers; 50-21-5/Lactic Acid; 502-44-3/caprolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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