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THE EFFECT OF CARBON DIOXIDE TENSION ON THE METABOLISM OF CEREBRAL CORTEX AND MEDULLA OBLONGATA.
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MedLine Citation:
PMID:  19873389     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Manometric measurements were made of oxygen uptake (Q(O(O2) )) and aerobic lactic acid output (Q(G)) by slices of cerebral cortex and medulla oblongata of the cat in the presence of mixtures of 1, 5, and 20 volumes per cent of carbon dioxide in oxygen. The concentrations of NaHCO(3) and NaCl in the medium were varied to maintain constant pH and sodium ion concentrations. The calcium ion concentration was 0.0002 M. At pH 7.5 under these conditions, an increase in carbon dioxide from 1 per cent to 5 per cent doubled the Q(G) of both tissues but did not alter Q(O(O2) ); an increase from 5 per cent to 20 per cent carbon dioxide had no further effect on Q(G) in either tissue or Q(O(O2) ) of cortex, but did depress the Q(O(O2) ) of medulla. At pH 8.1, an increase in carbon dioxide from 1 per cent to 5 per cent raised the Q(O(O2) ) and Q(G) of cortex by about 60 per cent. Measurements at low oxygen tension carried out previously in phosphate medium were repeated in bicarbonate medium to obtain data for the combined output of lactic acid and carbon dioxide (Q(A)). When the oxygen in the gas phase was decreased from 95 to 3 volumes per cent, the lactic acid output as measured colorimetrically increased by 114 mg./gm. in cortex and by 8 mg./gm. in medulla; Q(A) increased from 12.3 to 13.5 in cortex and decreased from 5.1 to 3.8 in medulla.
Authors:
F N Craig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of general physiology     Volume:  27     ISSN:  0022-1295     ISO Abbreviation:  J. Gen. Physiol.     Publication Date:  1944 Mar 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985110R     Medline TA:  J Gen Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-38     Citation Subset:  -    
Affiliation:
Anesthesia Laboratory of the Harvard Medical School at the Massachusetts General Hospital, Boston.
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Journal Information
Journal ID (nlm-ta): J Gen Physiol
ISSN: 0022-1295
ISSN: 1540-7748
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1944, by The Rockefeller Institute for Medical Research
Received Day: 6 Month: 11 Year: 1943
Print publication date: Day: 20 Month: 3 Year: 1944
Volume: 27 Issue: 4
First Page: 325 Last Page: 338
ID: 2238019
PubMed Id: 19873389

THE EFFECT OF CARBON DIOXIDE TENSION ON THE METABOLISM OF CEREBRAL CORTEX AND MEDULLA OBLONGATA
Francis N. Craig
From the Anesthesia Laboratory of the Harvard Medical School at the Massachusetts General Hospital, Boston


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