Document Detail

Effect of carbohydrates on calcium absorption in premature infants.
MedLine Citation:
PMID:  8848343     Owner:  NLM     Status:  MEDLINE    
Premature infants are susceptible to disease related to deficient dietary calcium intake. Studies in adults suggest carbohydrates can enhance calcium absorption. However, little is known about how carbohydrates affect calcium absorption in premature infants due to a lack of direct in vivo studies. We adapted the triple lumen perfusion method for use in premature infants to compare calcium absorption 36 mmol/L (1.44 g/L) in the absence and presence of either 70 g/L lactose or glucose polymers. 44Ca was added to determine endogenous calcium losses. Fourteen infants were studied (gestational age: 31 +/- 0.4 wk; study weight: 1590 +/- 105 g; mean +/- SEM). Calcium absorption from the glucose polymer solution was greater than that from the control and lactose solutions (0.17 +/- 0.05 versus 0.04 +/- 0.04 and 0.008 +/- 0.045, respectively). Calcium absorption correlated positively with water and carbohydrate absorption. The rate of carbohydrate absorption was greater from the glucose polymers than from the lactose solution (0.40 +/- 0.10 versus 0.22 +/- 0.06, respectively). Based upon 44Ca absorption, endogenous calcium loss appeared to account for less than 1% of total calcium flux. We conclude that glucose polymers, but not lactose, enhance calcium absorption in the premature infant, a fact that may be useful in formula design.
T H Stathos; R J Shulman; R J Schanler; S A Abrams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  39     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  666-70     Citation Subset:  IM    
USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
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MeSH Terms
Calcium, Dietary / metabolism*
Child, Preschool
Dietary Carbohydrates / pharmacology*
Enteral Nutrition
Glucose / metabolism
Infant, Low Birth Weight / metabolism
Infant, Newborn
Infant, Premature / metabolism*
Intestinal Absorption*
Lactose / metabolism
Vitamin D / pharmacology
Water / metabolism
Grant Support
Reg. No./Substance:
0/Calcium, Dietary; 0/Dietary Carbohydrates; 1406-16-2/Vitamin D; 50-99-7/Glucose; 63-42-3/Lactose; 7732-18-5/Water

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