| Effect of carbohydrates on calcium absorption in premature infants. | |
MedLine Citation:
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PMID: 8848343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Premature infants are susceptible to disease related to deficient dietary calcium intake. Studies in adults suggest carbohydrates can enhance calcium absorption. However, little is known about how carbohydrates affect calcium absorption in premature infants due to a lack of direct in vivo studies. We adapted the triple lumen perfusion method for use in premature infants to compare calcium absorption 36 mmol/L (1.44 g/L) in the absence and presence of either 70 g/L lactose or glucose polymers. 44Ca was added to determine endogenous calcium losses. Fourteen infants were studied (gestational age: 31 +/- 0.4 wk; study weight: 1590 +/- 105 g; mean +/- SEM). Calcium absorption from the glucose polymer solution was greater than that from the control and lactose solutions (0.17 +/- 0.05 mumol.min-1.cm-1 versus 0.04 +/- 0.04 and 0.008 +/- 0.045 mumol.min-1.cm-1, respectively). Calcium absorption correlated positively with water and carbohydrate absorption. The rate of carbohydrate absorption was greater from the glucose polymers than from the lactose solution (0.40 +/- 0.10 mg.min-1.cm-1 versus 0.22 +/- 0.06, respectively). Based upon 44Ca absorption, endogenous calcium loss appeared to account for less than 1% of total calcium flux. We conclude that glucose polymers, but not lactose, enhance calcium absorption in the premature infant, a fact that may be useful in formula design. |
Authors:
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T H Stathos; R J Shulman; R J Schanler; S A Abrams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatric research Volume: 39 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-10-24 Completed Date: 1996-10-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 666-70 Citation Subset: IM |
Affiliation:
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USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcium, Dietary
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metabolism* Child, Preschool Dietary Carbohydrates / pharmacology* Enteral Nutrition Female Glucose / metabolism Humans Infant Infant, Low Birth Weight / metabolism Infant, Newborn Infant, Premature / metabolism* Intestinal Absorption* Lactose / metabolism Male Vitamin D / pharmacology Water / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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M01RR-00188/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium, Dietary; 0/Dietary Carbohydrates; 1406-16-2/Vitamin D; 50-99-7/Glucose; 63-42-3/Lactose; 7732-18-5/Water |
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