Document Detail

Effect of carbohydrate and vitamin B6 on fuel substrates during exercise in women.
MedLine Citation:
PMID:  3386501     Owner:  NLM     Status:  MEDLINE    
Pyridoxal 5'-phosphate is an essential co-factor for glycogen phosphorylase and certain enzymes in the alanine-glucose cycle. Glycogen phosphorylase is also proposed as a storage reservoir for vitamin B6. To examine the effect of vitamin B6 and carbohydrate on fuel substrates during exercise, 5 young/trained, 5 young/un-trained, and 5 post-menopausal/un-trained women were alternately fed four diets (varying carbohydrate and B6 level) over a 7-wk period. Subjects were exercised at the end of each dietary period at 80% VO2max for 20 min on a cycle ergometer. Blood was drawn pre-, post-, post-30, and post-60 min of exercise and analyzed for plasma pyridoxal 5'-phosphate, glucose, free fatty acid, and lactate. ANOVA showed no difference among groups or diets for lactate, although lactate was significantly different over time (P less than 0.0001) on all diets. ANOVA showed significant time x group x diet inter-actions for free fatty acid (P less than 0.05) and significant diet x time (P less than 0.04) and time x group (P less than 0.03) inter-actions for glucose. Supplementation and/or increased carbohydrate resulted in lower free fatty acid during exercise in all groups. ANOVA showed no difference in pyridoxal 5'-phosphate for groups with respect to diet or time, but did show a significant increase from pre- to post-exercise and a significant decrease from post- to post-60 min of exercise. These results indicate that a high-carbohydrate diet and/or supplemental vitamin B6 can alter plasma fuel substrates during exercise in women; however, the effect depends on age and level of training.
M M Manore; J E Leklem
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  20     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-08-08     Completed Date:  1988-08-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  233-41     Citation Subset:  IM; S    
Department of Foods and Nutrition, Oregon State University, Corvallis 97331.
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MeSH Terms
Age Factors
Blood Glucose / metabolism
Dietary Carbohydrates / pharmacology*
Fatty Acids / blood
Physical Exertion / drug effects*
Pyridoxal Phosphate / blood,  metabolism
Pyridoxine / pharmacology*
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Fatty Acids; 54-47-7/Pyridoxal Phosphate; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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