Document Detail

Effect of carbohydrate supplementation on walking performance in peripheral arterial disease: a preliminary physiologic study.
MedLine Citation:
PMID:  15557907     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In this preliminary study we tested the effect of short-term carbohydrate supplementation on carbohydrate oxidation and walking performance in peripheral arterial disease.
METHODS: Eleven patients with peripheral arterial disease and intermittent claudication and 8 healthy control subjects completed several weeks of baseline exercise testing, then were given supplementation for 3 days with a carbohydrate solution and placebo. Maximal walking time was assessed with a graded treadmill test. Carbohydrate oxidation during a submaximal phase of this test was measured with indirect calorimetry. At the end of baseline testing a biopsy specimen was taken from the gastrocnemius muscle, and the active fraction of pyruvate dehydrogenase complex activity was determined.
RESULTS: Carbohydrate supplementation resulted in a significant increase in body weight and carbohydrate oxidation during exercise in patients with intermittent claudication and control subjects. Maximal walking time decreased by 3% in control subjects, whereas it increased by 6% in patients with intermittent claudication (group x treatment interaction, P < .05). There was a wide range of performance responses to carbohydrate supplementation among patients with claudication (-3%-37%). This effect was greater in poorer performers, and was negatively correlated (P < .05) with muscle pyruvate dehydrogenase complex activity.
CONCLUSION: Preliminary data suggest that carbohydrate oxidation during exercise might contribute to exercise intolerance in more dysfunctional patients with intermittent claudication and that carbohydrate supplementation might be an effective therapeutic intervention in these patients.
Glenn A Barker; Simon Green; Philip J Walker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  40     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-23     Completed Date:  2004-12-17     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  932-8     Citation Subset:  IM    
School of Human Movement Studies, Queensland University of Technology.
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MeSH Terms
Case-Control Studies
Dietary Carbohydrates*
Dietary Supplements
Intermittent Claudication / diagnosis,  diet therapy*
Middle Aged
Multivariate Analysis
Peripheral Vascular Diseases / diagnosis,  diet therapy*
Physical Endurance / physiology
Pulmonary Gas Exchange
Reference Values
Sensitivity and Specificity
Severity of Illness Index
Walking / physiology*
Reg. No./Substance:
0/Dietary Carbohydrates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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