| Effect of carbogen on tumour oxygenation and 32P-colloid interstitial irradiation response. | |
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MedLine Citation:
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PMID: 20037480 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Interstitial irradiation therapy using radionuclides is a slow and continual process in which the effect is exerted gradually, thus improvement of the hypoxic status of the tumor will also take a long time. It has been known that carbogen delivery of 5-15 min increases tumor oxygenation. However, the long-term effect of carbogen breathing on hypoxic cells has not yet been determined, and little is know about the effect of carbogen breathing for sensitization to interstitial irradiation therapy. MATERIAL/METHODS: 99mTc-HL91(99mTc 4,9-diaza-3,3,10,10-tetramethyldodecan-2,1-dione dioxime) hypoxic imaging was performed in 10 mice bearing sarcoma 180 (S180) before and after 2 h carbogen breathing. Radioactivity ratios of tumor to contralateral limbs (T/L) of the 2 images were calculated and compared. Mice bearing S180 were subjected to long-term carbogen breathing (2 h/day for 24 days), and were treated with or without 32P-colloid. Tumor growth rate was observed in the S180-bearing mice. RESULTS: T/L of 99mTc-HL91 uptake before and after carbogen breathing was 1.872+/-0.391 and 1.354+/-0.189, respectively (t=4.476, P<0.01). In mice in the 32P-treated air breathing group and 32P-treated carbogen breathing group, tumor growth rate did not differ on day 12 after 32P-colloid treatment, and on day 24 the tumor volume was 2.728+/-0.469 and 2.237+/-0.603 cm3 (t=2.128, P<0.05), respectively, with tumor mass being 2.437+/-0.447 and 1.965+/-0.538 g (t=2.134, P<0.05), respectively. Conclusions: Long-term carbogen breathing can increase tumor oxygenation and continual carbogen breathing is necessary for enhancing the therapeutic effect of 32P-colloid interstitial irradiation. |
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Authors:
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Hong Wei Zhan; Hong Biao Liu; Cheng Kan Bao; Xiao Juan Ye; Hong Zhang; Gang Qiang He |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 16 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-28 Completed Date: 2010-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: BR11-6 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, People's Republic of China. zhanhw@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brachytherapy / methods* Carbon Dioxide / pharmacology*, therapeutic use Cell Hypoxia / drug effects, physiology Mice Mice, Inbred BALB C Organotechnetium Compounds Oximes Oxygen / pharmacology*, therapeutic use Phosphorus Radioisotopes Radiation-Sensitizing Agents / pharmacology*, therapeutic use Sarcoma 180 / drug therapy, radiotherapy* |
| Chemical | |
Reg. No./Substance:
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0/Organotechnetium Compounds; 0/Oximes; 0/Phosphorus Radioisotopes; 0/Radiation-Sensitizing Agents; 0/technetium Tc 99m 4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 8063-77-2/carbogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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