| Effect of carbogen (95% O2/5% CO2) on retinal oxygenation in dark-adapted anesthetized cats. | |
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MedLine Citation:
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PMID: 17852195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This work assessed the relative effects of inspiring carbogen (95% O(2)/5% CO2) and 100% O2 on intraretinal PO2 and oxygen consumption in the cat retina. Oxygen microelectrodes were used to measure the distribution of oxygen in the central retina of dark-adapted anesthetized cats during normoxia, 100% O2 breathing, and carbogen breathing. Profiles of oxygen tension (PO2) as a function of retinal depth were recorded. Changes in PO2 caused by the transient administration of carbogen and 100% oxygen were also measured at selected retinal depths. Average PO2 values at the choroid, at the boundary between the inner and outer retina, and across the inner retina were significantly higher during inspiration of carbogen than 100% O2. There were no significant differences among conditions in outer retinal oxygen consumption. During the transient gas administration, average changes in PO2 generally increased with depth. At the end of gas administration, the decay of PO2 within the retina occurred quickly, meaning that short-term gas administration may have little therapeutic value. |
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Authors:
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Christina K Chung; Robert A Linsenmeier |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Current eye research Volume: 32 ISSN: 0271-3683 ISO Abbreviation: Curr. Eye Res. Publication Date: 2007 Jul-Aug |
Date Detail:
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Created Date: 2007-09-13 Completed Date: 2007-10-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 699-707 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208-3107, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / metabolism Carbon Dioxide / administration & dosage* Cats Dark Adaptation / physiology* Electroretinography Hyperoxia / metabolism Ion-Selective Electrodes Male Microelectrodes Oxygen / administration & dosage, metabolism* Oxygen Consumption / physiology* Partial Pressure Respiratory Physiological Phenomena Retina / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY05034/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 8063-77-2/carbogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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