Document Detail


Effect of captopril on urinary cystine excretion in homozygous cystinuria.
MedLine Citation:
PMID:  2685368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined if captopril could reduce urinary cystine excretion in homozygous cystinuric patients. Seven patients were treated with 150 mg. captopril daily after determination of baseline 24-hour urine cystine excretion. All patients had a history of multiple cystine stones, and were on chronic fluid and alkalization therapy. Five patients had previously been on D-penicillamine. Cystine excretion studies were repeated 1 to 5 months after institution of captopril. Baseline 24-hour urinary cystine excretion ranged from 580 to 970 mg. per gm. creatinine (mean 744). After institution of captopril these levels decreased to a range of 113 to 581 mg. per gm. creatinine (mean 371). These values on treatment represented a statistically significant decrease to between 18 and 89% of baseline levels (p equals 0.0045). We conclude that captopril can significantly, and at times profoundly, decrease urinary cystine excretion in patients with homozygous cystinuria. Further studies are required to elucidate fully the mechanism of urinary cystine reduction and to help define a possible role for this drug in routine maintenance or dissolution therapy.
Authors:
S B Streem; P Hall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  142     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1989-12-28     Completed Date:  1989-12-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1522-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Urology, Cleveland Clinic Foundation, Ohio.
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MeSH Terms
Descriptor/Qualifier:
Adult
Captopril / therapeutic use*
Circadian Rhythm / drug effects
Creatinine / urine
Cystinuria / drug therapy*,  urine
Drug Evaluation
Female
Homozygote
Humans
Male
Middle Aged
Time Factors
Urinary Calculi / drug therapy,  urine
Chemical
Reg. No./Substance:
60-27-5/Creatinine; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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