| Effect of captopril on sympathetic preganglionic efferent activity in cats. | |
MedLine Citation:
|
PMID: 8447450 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In 13 decerebrate cats, we studied the effects of captopril (10 mg/kg iv bolus) on the background discharge of thoracic preganglionic sympathetic fibers. After drug administration there was an initial reduction in systolic arterial pressure (SAP), which was followed by a later inhibition of sympathetic discharge (from 2.7 +/- 0.5 to 0.79 +/- 0.1 imp/0.1 s; P < 0.01). Captopril significantly reduced the excitatory response of sympathetic fibers to premature ventricular contraction (70 +/- 17 vs. 257 +/- 30%), inferior vena cava obstruction (176 +/- 56 vs. 315 +/- 85%) and asphyxia (143 +/- 20 vs. 245 +/- 51%). Vice versa the sympathetic response to aortic occlusion was unaffected (-58 +/- 8 vs. -62 +/- 6%). A similar reduction in sympathetic discharge was observed after captopril administration in anesthetized cats (n = 3). On the contrary, no changes in background neural discharge were noticed in decerebrate-spinalized cats (n = 5), despite comparable hemodynamic effects. These data indicate that captopril reduces sympathetic efferent activity and its responsiveness to excitatory stimuli. The lack of neural effects in decerebrate-spinalized cats is consistent with a brain stem site of action of captopril. |
Authors:
|
N Montano; T Gnecchi-Ruscone; M Contini; M L Finocchiaro; F Lombardi; A Malliani |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of physiology Volume: 264 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1993 Feb |
Date Detail:
|
Created Date: 1993-04-06 Completed Date: 1993-04-06 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: H345-51 Citation Subset: IM |
Affiliation:
|
Centro Ricerche Cardiovascolari, Università di Milano, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Captopril / pharmacology* Cats Decerebrate State Efferent Pathways / drug effects, physiology Electrophysiology Ganglia, Sympathetic / drug effects*, physiology Reflex / drug effects |
| Chemical | |
Reg. No./Substance:
|
62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Complement C5a-mediated myocardial ischemia and neutrophil sequestration: two independent phenomena.
Next Document: Tachyphylaxis to the vasopressor effects of endothelin in rat aortic rings.