| Effect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbits. | |
| | |
MedLine Citation:
|
PMID: 21777025 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Angiotensin converting enzyme inhibitors are widely used in therapy of cardiovascular diseases. However, the consensus on effects of these inhibitors in control of myocardial oxygen consumption during the process of experimental hypercholesterolemia and under the condition of endothelial dysfunction has not been reached. Here we examined effects of captopril, an angiotensin converting enzyme inhibitor, on serum lipid levels and oxygen consumption rate in mitochondria isolated from heart of rabbits treated by hypercholesterolemic diet. During the twelve-week period, the Chinchilla male rabbits were daily treated by saline (controls); 1 % cholesterol diet; 5 mg/kg/day captopril or 1 % cholesterol + 5 mg/kg/day captopril. Total- and high-density lipoprotein cholesterol and triglyceride in serum were measured spectrophotometricly. The left ventricle mitochondrial fraction was isolated and myocardial oxygen consumption was measured by Biological Oxygen Monitor. Mitochondria isolated from hearts of rabbits exposed to hypercholesterolemic diet showed significantly reduced respiration rates (state 3 and state 4) with altering adenosine diphosphate/oxygen ratio, whereas the respiratory control ratio was not affected when compared to controls. Mitochondria from cholesterol/captopril-treated animals showed significantly reduced respiration rates without altering adenosine diphosphate/oxygen ratio index or respiratory control ratio. Although captopril did not exert the favorable effect on serum lipid levels in cholesterol-treated animals, it restored the mitochondrial oxygen consumption. Further studies should be performed to define the underlying physiological and/or pathophysiological mechanisms and clinical implications. |
| | |
Authors:
|
Z Kojic; K Gopcevic; D Marinkovic; G Tasic |
Related Documents
:
|
15361355 - Short-term resistance to diet-induced obesity in a/j mice is not associated with regula... 8203615 - Insulin sensitivity of adipocytes from inbred mouse strains resistant or sensitive to d... 12183595 - Chlamydia pneumoniae and hyperlipidemia are co-risk factors for atherosclerosis: infect... 17353585 - Flaxseed reduces plasma cholesterol levels in hypercholesterolemic mouse models. 21775565 - Association of body fat percentage with lipid concentrations in children and adolescent... 7121295 - Weight reduction and oestrogen excretion in obese post-menopausal women. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-19 |
Journal Detail:
|
Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: - ISSN: 1802-9973 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Institute of Physiology, School of Medicine, University of Belgrade, Belgrade, Serbia. zvezdanak@med.bg.ac.rs. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development of the chloride homeostasis in the auditory brainstem.
Next Document: Calcium dependencies of regulated exocytosis in different endocrine cells.