| Effect of captopril and hydralazine on arterial pressure-urinary output relationships in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 3319899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin I converting enzyme inhibitors are typically classified as peripheral vasodilators. We studied the effect of captopril and a known vasodilator, hydralazine, on arterial pressure-urinary output relationships in adult spontaneously hypertensive rats to determine whether these drugs produced similar changes in this relationship. Tail-cuff pressure and 24-hour urine output and sodium excretion were measured under steady state conditions during ingestion of tap water or saline (1% NaCl) ad libitum. Sodium intake increased seven to nine times when rats drank saline, but in the absence of drug treatment, tail-cuff pressure was not altered significantly (water, 213 +/- 3 vs saline, 220 +/- 5 mm Hg). Daily administration of captopril (100 mg/kg p.o.) or hydralazine (15 mg/kg p.o.) for 2 weeks lowered tail-cuff pressure significantly (175 +/- 3 and 166 +/- 3 mm Hg, respectively; p less than 0.01) while rats drank tap water. Continued administration of hydralazine plus 2 weeks of drinking saline did not alter tail-cuff pressure (162 +/- 4 mm Hg), but with the addition of saline during captopril treatment, tail-cuff pressure was elevated significantly (210 +/- 5 mm Hg; p less than 0.01). Thus, hydralazine produced a parallel shift of the arterial pressure-urinary output relationship along the pressure axis. In contrast, captopril produced a marked change in the slope of this relationship, making arterial pressure extremely salt-sensitive. The results suggest that the two drugs have different effects on the mechanisms that contribute to the long-term control of arterial pressure.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R L Kline; P F Mercer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 10 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-02-02 Completed Date: 1988-02-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 590-4 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Western Ontario, London, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Captopril / therapeutic use* Hydralazine / therapeutic use* Hypertension / drug therapy*, physiopathology Kidney / drug effects* Kidney Concentrating Ability / drug effects Male Natriuresis / drug effects* Rats Rats, Inbred SHR Renin-Angiotensin System / drug effects Sodium Chloride / administration & dosage Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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62571-86-2/Captopril; 7647-14-5/Sodium Chloride; 86-54-4/Hydralazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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