| Effect of captopril on blood pressure, renal function, the electrolyte balance and the renin-angiotensin system in Bartter's syndrome. | |
| | |
MedLine Citation:
|
PMID: 6341865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
3 patients with Bartter's syndrome were studied under metabolic ward conditions before and during administration of captopril 25 mg t.i.d. The drug induced an immediate and sustained reduction of blood pressure (by 14 and 18% after 1 h and 3 days, respectively) with no change in heart rate. During treatment renal plasma flow increased by 29%, but the glomerular filtration rate was unchanged. Renal vascular resistance decreased by 41%. There was an increase in urinary sodium excretion with a corresponding reduction of body weight. The potassium balance was not affected. The concentration of angiotensin II became normal but the plasma renin concentration rose tenfold. Plasma renin substrate, initially rather low, was further reduced. The blood pressure responsiveness to angiotensin II increased without being completely normalized. An abnormal production of vasodilating prostaglandins is thought to be an important feature of Bartter's syndrome. Our findings, notably the marked renal vasodilatation, may reflect the effect of these prostaglandins when unopposed by an increased angiotensin II production. |
| | |
Authors:
|
M Aurell; A Rudin |
Related Documents
:
|
3319645 - Effect of the calcium antagonist nilvadipine on haemodynamics at rest and during cold s... 8737955 - Systemic, pulmonary, brachial, renal and hepato-splanchnic hemodynamic effects of spira... 9825185 - Neurohumoral response to carmoxirole, a selective dopamine (d2) receptor agonist, in pa... 1741995 - On the role of renin in one-kidney, one-clip hypertension. 11758945 - Clinical value of lung uptake of iodine-123 metaiodobenzylguanidine (mibg), a myocardia... 16671415 - Decompressive craniectomy in traumatic brain injury: the randomized multicenter rescuei... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Nephron Volume: 33 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1983 |
Date Detail:
|
Created Date: 1983-06-23 Completed Date: 1983-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 274-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Bartter Syndrome / drug therapy*, metabolism, physiopathology Blood Pressure* Body Weight Captopril / therapeutic use* Female Humans Hyperaldosteronism / drug therapy* Kidney* / physiopathology Male Potassium / metabolism Proline / analogs & derivatives* Renin-Angiotensin System* Sodium / metabolism |
| Chemical | |
Reg. No./Substance:
|
147-85-3/Proline; 62571-86-2/Captopril; 7440-09-7/Potassium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Carbohydrate metabolism in patients with nephrotic syndrome and normal renal function.
Next Document: Minoxidil treatment of refractory arterial hypertension following a kidney transplant