Document Detail

Effect of caloric restriction on nitric oxide production, ACE activity, and blood pressure regulation in rats.
MedLine Citation:
PMID:  18389998     Owner:  NLM     Status:  MEDLINE    
High calorie intake and high weight gain is one of the worldwide health problems particularly in industrial and developed countries. The subjected individuals are at high risk for developing various disorders such as diabetes and particularly cardiovascular problems. It has been well established that life style modification plays an important role in reducing these problems, particularly weight reduction and caloric restriction (CR) as a non-pharmacological approach. This study sought to examine the possible effect of caloric restriction on nitric oxide production, ACE activity and blood pressure regulation in rat. Two groups of rats were selected as the control (C) and the CR group and a with standard and an every other day diet, respectively, for 4 weeks. At the end of study in the CR group systolic blood pressure was significantly decreased compared to controls. The serum NOx was significantly increased compared to the C group. The serum ACE activity was lower in the CR group. Therefore, it may be concluded that CR could reduce blood pressure by elevating NO production and lowering ACE activity.
A M Sharifi; S Mohseni; S Nekoparvar; B Larijani; H Fakhrzadeh; S Oryan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  95     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  55-63     Citation Subset:  IM    
Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P.O. Box 14155-6183, Tehran, Iran.
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MeSH Terms
Aorta / enzymology
Blood Glucose / analysis
Blood Pressure*
Caloric Restriction*
Hypertension / diet therapy
Myocardium / enzymology
Nitric Oxide / blood*
Peptidyl-Dipeptidase A / metabolism*
Rats, Wistar
Reg. No./Substance:
0/Blood Glucose; 10102-43-9/Nitric Oxide; EC A

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