Document Detail


Effect of caloric restriction on nitric oxide production, ACE activity, and blood pressure regulation in rats.
MedLine Citation:
PMID:  18389998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High calorie intake and high weight gain is one of the worldwide health problems particularly in industrial and developed countries. The subjected individuals are at high risk for developing various disorders such as diabetes and particularly cardiovascular problems. It has been well established that life style modification plays an important role in reducing these problems, particularly weight reduction and caloric restriction (CR) as a non-pharmacological approach. This study sought to examine the possible effect of caloric restriction on nitric oxide production, ACE activity and blood pressure regulation in rat. Two groups of rats were selected as the control (C) and the CR group and a with standard and an every other day diet, respectively, for 4 weeks. At the end of study in the CR group systolic blood pressure was significantly decreased compared to controls. The serum NOx was significantly increased compared to the C group. The serum ACE activity was lower in the CR group. Therefore, it may be concluded that CR could reduce blood pressure by elevating NO production and lowering ACE activity.
Authors:
A M Sharifi; S Mohseni; S Nekoparvar; B Larijani; H Fakhrzadeh; S Oryan
Related Documents :
7922188 - Kinins as vasoactive peptides.
1720478 - Evaluation of isradipine and captopril alone or in combination for the treatment of hyp...
9732338 - Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular ...
3039218 - Hypotensive effect of sa446, an angiotensin converting enzyme inhibitor, in 2-kidney, 1...
366118 - Influence of pressure and vibration during cementation.
23561068 - Rheumatoid arthritis in upper limbs benefits from moderate pressure massage therapy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  95     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  55-63     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P.O. Box 14155-6183, Tehran, Iran. sharifal@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / enzymology
Blood Glucose / analysis
Blood Pressure*
Caloric Restriction*
Hypertension / diet therapy
Male
Myocardium / enzymology
Nitric Oxide / blood*
Peptidyl-Dipeptidase A / metabolism*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Blood Glucose; 10102-43-9/Nitric Oxide; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Characteristics of the myogenic behaviour of arteries of the common European frog (Rana temporaria).
Next Document:  Prolonged melatonin administration in 6-month-old Sprague-Dawley rats: metabolic alterations.