| Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. | |
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MedLine Citation:
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PMID: 2346674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucarate is normally present in tissues and body fluids and is in equilibrium with D-glucaro-1,4-lactone, a natural inhibitor of beta-glucuronidase activity. Dietary calcium glucarate, a sustained-release from of glucarate, elevates the blood level of D-glucaro-1,4-lactone which suppresses blood and tissue beta-glucuronidase activity. A single dose of CaG (4.5 mmole/kg body weight) inhibited beta-glucuronidase activity in serum and liver, lung, and intestinal microsomes by 57, 44, 37, and 39%, respectively. A chronic administration of calcium glucarate (4% in diet) also decreased beta-glucuronidase activity in intestinal and liver microsomes. Maximal inhibition of beta-glucuronidase activity in serum was observed from 12 noon to 2:00 PM. In contrast, maximum inhibition of beta-glucuronidase activity in intestinal and liver microsomes occurred during mornings, although a secondary depression in intestinal microsomes also occurred around 4 PM. A 4% calcium glucarate supplemented diet also inhibited beta-glucuronidase activity by 70% and 54%, of the bacterial flora obtained from proximal (small intestine) and distal (colon) segments of intestine, respectively. Due to the potential effect of dietary glucarate on net glucuronidation and on other metabolic pathways, glucaric acid levels in various foods were determined. The glucaric acid content varied from a low of 1.12-1.73 mg/100 g for broccoli and potatoes to a high of 4.53 mg/100 g for oranges. |
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Authors:
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C Dwivedi; W J Heck; A A Downie; S Larroya; T E Webb |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical medicine and metabolic biology Volume: 43 ISSN: 0885-4505 ISO Abbreviation: Biochem. Med. Metab. Biol. Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-07-12 Completed Date: 1990-07-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8605718 Medline TA: Biochem Med Metab Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 83-92 Citation Subset: IM |
Affiliation:
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College of Pharmacy, South Dakota State University, Brookings 57007. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Circadian Rhythm Enterobacteriaceae / enzymology Female Fruit / analysis* Glucaric Acid / analysis*, pharmacology* Glucuronidase / antagonists & inhibitors*, blood, metabolism Intestines / enzymology, microbiology Lung / enzymology Microsomes / enzymology Microsomes, Liver / enzymology Rats Rats, Inbred F344 Sugar Acids / analysis*, pharmacology* Vegetables / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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CA38125/CA/NCI NIH HHS; P30-CA 16058-13/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sugar Acids; 25525-21-7/Glucaric Acid; EC 3.2.1.31/Glucuronidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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