Document Detail

Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women.
MedLine Citation:
PMID:  17030114     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We compared the effect of supplementation with a fortified skimmed milk product (high calcium skim milk) with or without added phylloquinone (vitamin K(1)) on markers of bone formation and resorption in premenopausal women. METHODS: Eighty-two women 20 to 35 y of age were randomly allocated to three groups. Two groups received two daily servings of high calcium skim milk (1000 mg/d of extra calcium) with or without added phylloquinone (80 microg/d) for 16 wk, and a third control group received no supplementation. Bone density was assessed at baseline and the bone markers, total osteocalcin, type I N-terminal procollagen peptide, and cross-linked C-telopeptide of type I collagen were measured at baseline and at weeks 2, 12, and 16. Serum phylloquinone and undercarboxylated osteocalcin were measured in the control and vitamin K-supplemented groups at weeks 0 and 16. RESULTS: Baseline values for age, body mass index, and bone density did not differ across groups. In vitamin K-supplemented women, mean serum phylloquinone concentrations increased from 0.27 to 0.76 microg/L (P < 0.05) and undercarboxylated osteocalcin concentrations decreased from 9.68 to 4.46 microg/L (P < 0.05) over 16 wk. Plasma cross-linked C-telopeptide of type I collagen, total osteocalcin, and type I N-terminal procollagen peptide levels decreased significantly in both supplemented groups compared with the control group over 16 wk (cross-linked C-telopeptide of type I collagen >30%, total osteocalcin and type I N-terminal procollagen peptide >15%). CONCLUSION: Fortified milk supplementation in premenopausal women reduced bone turnover significantly. Phylloquinone fortification substantially improved vitamin K status but had no demonstrable additive effect on bone turnover in this short-term study.
Marlena C Kruger; Christine L Booth; Jane Coad; Linda M Schollum; Barbara Kuhn-Sherlock; Martin J Shearer
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-10-09
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  22     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-11-10     Completed Date:  2007-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1120-8     Citation Subset:  IM    
Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand.
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MeSH Terms
Biological Markers / blood
Bone Density / drug effects*
Bone Resorption / prevention & control
Bone and Bones / drug effects,  metabolism*
Calcium, Dietary / administration & dosage*
Collagen Type I / blood
Food, Fortified*
Milk / chemistry
Osteocalcin / blood
Peptide Fragments / blood
Peptides / blood
Premenopause / blood
Procollagen / blood
Vitamin K 1 / administration & dosage*,  blood
Vitamins / administration & dosage,  blood
Reg. No./Substance:
0/Biological Markers; 0/Calcium, Dietary; 0/Collagen Type I; 0/Peptide Fragments; 0/Peptides; 0/Procollagen; 0/Vitamins; 0/collagen type I trimeric cross-linked peptide; 0/procollagen type I carboxy terminal peptide; 104982-03-8/Osteocalcin; 84-80-0/Vitamin K 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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