| Effect of calcium channel blockers on cerebral ischemia-induced hyperactivity in Mongolian gerbils. | |
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MedLine Citation:
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PMID: 10549896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When both common carotid arteries of Mongolian gerbils were occluded for 5 min to produce ischemic insult, locomotor activity was increased the following day. The effect of calcium channel blockers on this ischemia-induced hyperactivity was investigated. Nimodipine, at doses of 5, 10, and 20 mg/kg, dose dependently and significantly decreased ischemia-induced hyperactivity. Nicardipine significantly decreased ischemia-induced hyperactivity and doses of 10 and 20 mg/kg. Nifedipine and flunaridine also significantly decreased ischemia-induced hyperactivity at doses of 20 mg/kg. Verapamil had no effect on ischemia-induced hyperactivity at a dose of 20 mg/kg. These findings suggest that ischemia-induced hyperactivity is related to calcium channels. These relationship between calcium channels and dopaminergic function is discussed. |
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Authors:
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H Araki; N Hino; Y Karasawa; H Kawasaki; Y Gomita |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiology & behavior Volume: 67 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-12-13 Completed Date: 1999-12-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 573-7 Citation Subset: IM |
Affiliation:
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Hospital Pharmacy Department, Okayama University Medical School, Japan. haraki@hospital.okayama-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / psychology* Calcium Channel Blockers / pharmacology* Carotid Artery, Common / physiology Gerbillinae Hippocampus / anatomy & histology, drug effects Hyperkinesis / psychology* Male Motor Activity / physiology |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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