| Effect of calcium channel blockade or angiotensin-converting enzyme inhibition on structure of coronary, renal, and other small arteries in spontaneously hypertensive rats. | |
| | |
MedLine Citation:
|
PMID: 8797138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto control rats (WKY) were treated for 14 weeks with a novel calcium channel blocker, mibefradil (Ro40-5967), or an angiotensin-converting enzyme inhibitor, cilazapril. Blood pressure was significantly reduced by treatment in SHRs from > 200 mm Hg to 155 +/- 2 mm Hg by mibefradil and to 138 +/- 1 mm Hg by cilazapril (p < 0.01). Cardiac hypertrophy was significantly reduced by treatment but to a greater degree with cilazapril than with mibefradil. Conduit and large arteries also had significant regression of hypertrophy. Small arteries (luminal diameter, 200-300 microns) of the coronary, renal, mesenteric, and femoral circulations exhibited significant hypertrophy and remodeling in SHRs in comparison to WKYs. Cilazapril treatment resulted in increased lumen, reduced media thickness, and media-to-lumen ratio in all four vascular beds. Mibefradil treatment induced regression of luminal diameter to a significant degree only in the mesenteric and femoral small arteries but decreased media thickness and media to lumen diameter in all four vascular beds. The greater extent of regression of cardiac and vascular hypertrophy and remodeling with cilazapril than with mibefradil may relate to the degree of blood pressure reduction, which, with the doses used, was larger with the angiotensin-converting enzyme inhibitor than with the calcium channel blocker. In WKY rats, treatment had no effect except with cilazapril on lumen diameter of small arteries and with mibefradil on heart weight, both of which increased. These results demonstrate the blood-pressure dependence of regression of cardiovascular hypertrophy and remodeling and the possibility of achieving "reverse remodeling" of large and small arteries with converting enzyme inhibition or calcium channel blockade in SHRs, as well as the near absence of effects of these agents on cardiovascular characteristics in WKYs. |
| | |
Authors:
|
J S Li; E L Schiffrin |
Related Documents
:
|
4059388 - Blood pressure and heart rate responses to environmental stress in the spontaneously hy... 1550668 - Effects of nifedipine and moxonidine on cardiac structure in spontaneously hypertensive... 7081448 - Favorable effects of therapy on cardiac performance in spontaneously hypertensive rats. 18703778 - Chronic hypoxia-induced angiogenesis normalizes blood pressure in spontaneously hyperte... 16489848 - Vasopressin during cardiopulmonary resuscitation and different shock states: a review o... 2584698 - The development of hypertension care in finland from 1982 to 1987. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 28 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1996 Jul |
Date Detail:
|
Created Date: 1997-01-06 Completed Date: 1997-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 68-74 Citation Subset: IM |
Affiliation:
|
Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin-Converting Enzyme Inhibitors
/
pharmacology* Animals Benzimidazoles / pharmacology* Blood Pressure / drug effects Calcium Channel Blockers / pharmacology* Cilazapril / pharmacology* Coronary Vessels / drug effects*, pathology Femoral Artery / drug effects, pathology Heart / drug effects Hypertension / drug therapy Mesenteric Arteries / drug effects, pathology Mibefradil Microcirculation / drug effects*, pathology Rats Rats, Inbred SHR Rats, Inbred WKY Renal Artery / drug effects*, pathology Renin / blood Tetrahydronaphthalenes / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzimidazoles; 0/Calcium Channel Blockers; 0/Tetrahydronaphthalenes; 116644-53-2/Mibefradil; 92077-78-6/Cilazapril; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impairment of coronary blood flow regulation by endothelium-derived nitric oxide in dogs with alloxa...
Next Document: Reversal by L- and D-enantiomers of NG-nitro-arginine of endotoxin-induced hypotension and vascular ...