Document Detail

Effect of calcium antagonists on histamine release from human basophil leukocytes.
MedLine Citation:
PMID:  2429685     Owner:  NLM     Status:  MEDLINE    
The effect of calcium antagonists on basophil activation was investigated in 14 subjects. Verapamil, methoxyverapamil and diltiazem, in a concentration range of 1-100 microM, exert a concentration-dependent inhibition on the human basophil histamine release induced by calcium ionophore A23187, zymosan activated human serum and grass pollen allergens. This inhibitory effect is highly variable from subject to subject and from drug to drug. At concentrations higher than 200 microM, verapamil, methoxyverapamil and diltiazem induce a calcium independent histamine secretion from basophil leukocytes. This mediator release is associated with an increase in LDH levels in the cell supernatant and seems to be due to a cytotoxic effect.
A Miadonna; A Tedeschi; E Leggieri; M Lorini; M Froldi; C Zanussi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  22     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-10     Completed Date:  1986-12-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  483-6     Citation Subset:  IM    
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MeSH Terms
Basophils / drug effects*
Calcium Channel Blockers / pharmacology*
Diltiazem / pharmacology
Dose-Response Relationship, Drug
Gallopamil / pharmacology
Histamine Release / drug effects*
Verapamil / pharmacology
Reg. No./Substance:
0/Calcium Channel Blockers; 16662-47-8/Gallopamil; 42399-41-7/Diltiazem; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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