Document Detail

Effect of the calcium antagonist nilvadipine on haemodynamics at rest and during cold stimulation in essential hypertension.
MedLine Citation:
PMID:  3319645     Owner:  NLM     Status:  MEDLINE    
The immediate haemodynamic effects of the calcium antagonist nilvadipine have been studied in ten patients with established mild essential hypertension. Nilvadipine 4 mg p.o. reduced both the systolic and diastolic blood pressures within 60 min, associated with a fall in total peripheral resistance and an increase in heart rate and cardiac index. The peak of blood pressure and total peripheral resistance reached during a cold pressor test were reduced by nilvadipine, but it did not affect the haemodynamic responsiveness to cold stimulation. Plasma renin activity was unaltered and the plasma noradrenaline concentration was increased only slightly. Thus, nilvadipine lowered blood pressure at rest and during cold stimulation as a result of arteriolar dilatation. The hypotensive effect at rest was associated with a reflex increase in heart rate and cardiac index.
T Takabatake; Y Yamamoto; S Nakamura; N Hashimoto; S Satoh; Y Yamada; H Ohta; N Hattori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  33     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-02-03     Completed Date:  1988-02-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  215-9     Citation Subset:  IM    
First Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
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MeSH Terms
Calcium Channel Blockers / pharmacology*
Catecholamines / blood
Cold Temperature*
Hemodynamics / drug effects*
Hypertension / drug therapy*,  physiopathology
Middle Aged
Nifedipine / analogs & derivatives*,  pharmacology
Renin / blood
Vascular Resistance / drug effects
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Catecholamines; 21829-25-4/Nifedipine; 75530-68-6/nilvadipine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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