Document Detail

Effect of calcitonin treatment on the natural course of bone demineralization in Paget's disease.
MedLine Citation:
PMID:  6822644     Owner:  NLM     Status:  MEDLINE    
Numerous studies have been done to determine the effects of long term calcitonin (CT) treatment on Paget's disease of bone, but very few studies have been undertaken to determine the long term CT effect on nonpagetic bone in man. Because of conflicting results of the CT effect on osteoporosis and also for further understanding of the role of CT on normal bone, we conducted a longitudinal prospective study on the effect of CT treatment on nonpagetic bone in patients with Paget's disease using monoenergetic photon absorptionmetry method. Patients with Paget's disease were given salmon CT daily for a period of 3 yr, the bone mineral content (BMC) in the nonpagetic distal radius was measured periodically for 3 yr, and the data were compared with those of the control group of patients with Paget's disease not receiving CT treatment. It was found that the control group showed a persistent gradual decrease in BMC during the study period of 3 yr, but the CT-treated group showed no decrease in BMC during the 3-yr period of treatment. Our study suggests that CT treatment may delay the natural course of bone demineralization with aging in patients with Paget's disease.
S H Toh; B C Claunch; P H Brown
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  56     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-9     Citation Subset:  AIM; IM; S    
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MeSH Terms
Alkaline Phosphatase / metabolism
Bone and Bones / metabolism*
Calcitonin / therapeutic use*
Longitudinal Studies
Middle Aged
Minerals / metabolism*
Osteitis Deformans / drug therapy,  metabolism*
Prospective Studies
Reg. No./Substance:
0/Minerals; 9007-12-9/Calcitonin; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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