Document Detail

Effect of calcitonin gene-related peptide (CGRP), adrenomedullin and adrenomedullin-2/intermedin on food intake in goldfish (Carassius auratus).
MedLine Citation:
PMID:  19150637     Owner:  NLM     Status:  MEDLINE    
The purpose of the present study was to elucidate the possible role of calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and adrenomedullin-2/intermedin (IMD) on food intake regulation in goldfish (Carassius auratus). We examined the effects of intracerebroventricular (ICV) administration of these related hormones on food intake. Food-deprived goldfish were subjected to ICV injections of CGRP, AM and IMD and their food intake were quantified. CGRP at 10ng/g body weight (bw) significantly decreased food intake as compared to saline-treated fish. IMD at 10 and 50ng/g bw both significantly decreased food intake as compared to saline group. No significant differences were observed after AM administration. Our results suggest, for the first time in fish, a role for both CGRP and IMD in the central regulation of feeding in fish.
R M Martínez-Alvarez; H Volkoff; J A Muñoz-Cueto; M J Delgado
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-27
Journal Detail:
Title:  Peptides     Volume:  30     ISSN:  1873-5169     ISO Abbreviation:  Peptides     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  803-7     Citation Subset:  IM    
Departamento de Biología, Universidad de Cádiz, Puerto Real, Spain.
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MeSH Terms
Adrenomedullin / administration & dosage,  chemistry,  pharmacology*
Amino Acid Sequence
Body Weight / drug effects
Calcitonin Gene-Related Peptide / administration & dosage,  pharmacology*
Feeding Behavior / drug effects*
Injections, Intraventricular
Molecular Sequence Data
Reg. No./Substance:
148498-78-6/Adrenomedullin; 83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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