| Effect of caffeine on control of breathing in infantile apnea. | |
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MedLine Citation:
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PMID: 6644439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abnormalities in control of breathing have been associated with near-miss sudden infant death syndrome. Because caffeine is a respiratory stimulant, its effect on breathing pattern was evaluated in 12 infants with infantile apnea. Caffeine induced a significant increase in ventilation, tidal volume, and mean inspiratory flow. In contrast, no changes were noted in inspiratory time, expiratory time, or total cycle duration. These effects were observed with plasma concentrations of caffeine ranging from 8 to 20 mg/L. Caffeine increases ventilation mainly by increasing central inspiratory drive, and not be effective timing (T1/TTOT). This drug may be of value in near-miss SIDS. |
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Authors:
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J V Aranda; T Turmen; J Davis; T Trippenbach; D Grondin; R Zinman; G Watters |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 103 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1984-01-26 Completed Date: 1984-01-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 975-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apnea
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drug therapy* Caffeine / administration & dosage, pharmacology, therapeutic use* Dose-Response Relationship, Drug Humans Infant, Newborn Maximal Voluntary Ventilation Pulmonary Ventilation / drug effects Respiration / drug effects* Respiratory Function Tests Sudden Infant Death / prevention & control |
| Chemical | |
Reg. No./Substance:
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58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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