Document Detail

Effect of caffeic acid phenethyl ester on gastric acid secretion in vitro.
MedLine Citation:
PMID:  16183057     Owner:  NLM     Status:  MEDLINE    
Caffeic acid phenethyl ester (CAPE), one of the major components of propolis (honeybee resin), has demonstrated a wide spectrum of activities including suppression of eicosanoids by inhibition of cyclooxygenase-1 and cyclooxygenase-2 enzyme activities. The aim of this study was to investigate the effect of CAPE on basal and secretagogues-stimulated gastric acid secretion in vitro. In the isolated, lumen-perfused, stomach preparation of mouse, CAPE (10-100 microM) did not affect the basal gastric acid secretion nor the secretion stimulated by histamine, pentagastrin, isobutyl methylxanthine and high levels of K+. By contrast, CAPE increased the gastric acid secretion induced by the muscarinic receptor agonist, 5-methylfurmethide (5-MEF). CAPE also inhibited the acetylcholinesterase activity in an in vitro colorimetric assay. Eserine (10 microM), a well known acetylcholinesterase inhibitor, also increased 5-MEF-stimulated acid secretion. Our results show that CAPE increases gastric acid secretion stimulated by an acetylcholine agonist receptor likely through inhibition of acetylcholinesterase activity.
Francesca Borrelli; Inmaculada Posadas; Raffaele Capasso; Gabriella Aviello; Valeria Ascione; Francesco Capasso
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-23
Journal Detail:
Title:  European journal of pharmacology     Volume:  521     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-11     Completed Date:  2006-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Department of Experimental Pharmacology, University of Naples Federico II, Via D. Montesano 49, 80131, Naples, Italy.
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MeSH Terms
1-Methyl-3-isobutylxanthine / pharmacology
Acetylcholinesterase / metabolism
Caffeic Acids / pharmacology*
Cholinesterase Inhibitors / pharmacology
Dose-Response Relationship, Drug
Gastric Acid / secretion*
Gastrointestinal Agents / pharmacology
Histamine / pharmacology
Mice, Inbred ICR
Muscarine / analogs & derivatives,  pharmacology
Nifedipine / pharmacology
Pentagastrin / pharmacology
Phenylethyl Alcohol / analogs & derivatives*,  pharmacology
Physostigmine / pharmacology
Potassium / pharmacology
Stomach / drug effects*,  metabolism
Reg. No./Substance:
0/Caffeic Acids; 0/Cholinesterase Inhibitors; 0/Gastrointestinal Agents; 104594-70-9/caffeic acid phenethyl ester; 14172-53-3/5-methylfurtrethonium; 21829-25-4/Nifedipine; 28822-58-4/1-Methyl-3-isobutylxanthine; 300-54-9/Muscarine; 51-45-6/Histamine; 5534-95-2/Pentagastrin; 57-47-6/Physostigmine; 60-12-8/Phenylethyl Alcohol; 7440-09-7/Potassium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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