Document Detail

Effect of cadmium on enzymatic digestion and sugar transport in the small intestine of rabbit.
MedLine Citation:
PMID:  7504939     Owner:  NLM     Status:  MEDLINE    
Cadmium compounds are found widely in our environment: for example, in food, water, soil, and ambient air. The most important exposure route of animals to cadmium in the general environment is via oral exposure. In oral cadmium intoxication, the immediate target organ is the gastrointestinal tract. The aim of the present work was to determine how cadmium acts on the intestinal absorption of sugars and on the sucrase activity through rabbit jejunum, after in vitro administration and/or oral administration of CdCl2 in drinking water. Results obtained show that cadmium decreases D-galactose accumulation in the jejunum tissue. This effect seems to be the results of an action mainly located on Na(+)-dependent sugar transport of the mucosal border of the intestinal epithelium, because cadmium seems not to modify the sugar diffusion across the intestinal epithelium. Cadmium has also been shown to inhibit the (Na(+)-K+)-ATPase activity of the enterocyte, which might explain the inhibition of the D-galactose Na(+)-dependent transport. Nevertheless, a direct action of the cadmium molecule on the Na(+)-dependent carrier cannot be discarded. Cadmium altered the sucrose activity when it was administered in the drinking water for 4 d.
J E Mesonero; M C Rodríguez Yoldi; M J Rodríguez Yoldi
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  38     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-01-19     Completed Date:  1994-01-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-26     Citation Subset:  IM    
Facultad de Veterinaria, Universidad de Zaragoza, Spain.
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MeSH Terms
Adenosine Triphosphatases / antagonists & inhibitors,  metabolism
Body Water / metabolism
Cadmium / pharmacology*
Carbohydrates / pharmacokinetics*
Cation Transport Proteins*
Galactose / pharmacokinetics
Intestinal Absorption / drug effects*
Intestinal Mucosa / drug effects,  enzymology,  metabolism
Intestine, Small / drug effects,  enzymology,  metabolism*
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors,  metabolism
Sucrase / metabolism
Reg. No./Substance:
0/Carbohydrates; 0/Cation Transport Proteins; 26566-61-0/Galactose; 7440-43-9/Cadmium; EC; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/sodium-translocating ATPase; EC ATPase

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