Document Detail

Effect of cadmium on enzymatic digestion and sugar transport in the small intestine of rabbit.
MedLine Citation:
PMID:  7504939     Owner:  NLM     Status:  MEDLINE    
Cadmium compounds are found widely in our environment: for example, in food, water, soil, and ambient air. The most important exposure route of animals to cadmium in the general environment is via oral exposure. In oral cadmium intoxication, the immediate target organ is the gastrointestinal tract. The aim of the present work was to determine how cadmium acts on the intestinal absorption of sugars and on the sucrase activity through rabbit jejunum, after in vitro administration and/or oral administration of CdCl2 in drinking water. Results obtained show that cadmium decreases D-galactose accumulation in the jejunum tissue. This effect seems to be the results of an action mainly located on Na(+)-dependent sugar transport of the mucosal border of the intestinal epithelium, because cadmium seems not to modify the sugar diffusion across the intestinal epithelium. Cadmium has also been shown to inhibit the (Na(+)-K+)-ATPase activity of the enterocyte, which might explain the inhibition of the D-galactose Na(+)-dependent transport. Nevertheless, a direct action of the cadmium molecule on the Na(+)-dependent carrier cannot be discarded. Cadmium altered the sucrose activity when it was administered in the drinking water for 4 d.
J E Mesonero; M C Rodríguez Yoldi; M J Rodríguez Yoldi
Related Documents :
11202709 - Sources, distribution and variability of airborne trace metals in la plata city area, a...
12504169 - Cadmium, copper and nickel levels in vegetables from industrial and residential areas o...
15516769 - Metal elution and content of fused slags produced from incinerated ash.
7801109 - Accumulation of cadmium associated with sewage sludge by a marine amphipod crustacean.
17884259 - Comparative accumulation of (109)cd and (75)se from water and food by an estuarine fish...
8957189 - Analysis of interaction between cadmium and metallothionein isoforms by capillary zone ...
16558669 - Herbal supplements: considerations for the athletic trainer.
24561969 - Nutritional standards for energy-dense low-nutrient density foods for children in korea.
1760999 - Changes in hedonic responses to sweet and fat in recently diagnosed non-insulin-depende...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  38     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-01-19     Completed Date:  1994-01-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-26     Citation Subset:  IM    
Facultad de Veterinaria, Universidad de Zaragoza, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Triphosphatases / antagonists & inhibitors,  metabolism
Body Water / metabolism
Cadmium / pharmacology*
Carbohydrates / pharmacokinetics*
Cation Transport Proteins*
Galactose / pharmacokinetics
Intestinal Absorption / drug effects*
Intestinal Mucosa / drug effects,  enzymology,  metabolism
Intestine, Small / drug effects,  enzymology,  metabolism*
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors,  metabolism
Sucrase / metabolism
Reg. No./Substance:
0/Carbohydrates; 0/Cation Transport Proteins; 26566-61-0/Galactose; 7440-43-9/Cadmium; EC; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/sodium-translocating ATPase; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Specificity of antibody-dependent cellular cytotoxicity in sera from human immunodeficiency virus ty...
Next Document:  Plasma molybdenum concentrations in children with and without phenylketonuria.