Document Detail

Effect of butorphanol administration on cardiovascular parameters in isoflurane-anesthetized horses - a retrospective clinical evaluation.
MedLine Citation:
PMID:  17696970     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine cardiovascular responses to administration of butorphanol in isoflurane-anesthetized horses. STUDY DESIGN: Retrospective evaluation of anesthetic records. ANIMALS: Seventy-six horses anesthetized for a variety of clinical surgical procedures. METHODS: Anesthetic records of clinical equine patients anesthetized between January 1999 and December 2003 were searched. The records were reviewed for horses in which anesthesia was induced with ketamine and a benzodiazepine and maintained with isoflurane, and horses that received butorphanol intraoperatively. Exclusion criteria included horses in which the rate of infusion of an inotrope or end-tidal isoflurane concentration was changed 10 minutes before or after the butorphanol bolus. The horses were separated into two groups: group 1 horses received butorphanol at intervals as part of a balanced protocol, group 2 horses had > or = 10% increase in heart rate (HR) or blood pressure within 10 minutes prior to butorphanol administration. RESULTS: Eighty-nine butorphanol administration events matched the criteria for inclusion, 49 in group 1 and 40 in group 2. There were no significant changes after butorphanol administration in systolic arterial pressure (SAP), mean arterial pressure (MAP), diastolic arterial pressure (DAP), and heart rate (HR) in group 1, or in end-tidal carbon dioxide concentration or hemoglobin oxygen saturation in either group. There were significant decreases in SAP (p < 0.0001), MAP (p < 0.0005), and DAP (p < 0.0008) after butorphanol administration in group 2. CONCLUSIONS AND CLINICAL RELEVANCE: The results presented here confirm that butorphanol can be administered to horses during isoflurane anesthesia without adverse effects on HR and arterial blood pressure. The results imply that butorphanol can deepen the plane of anesthesia and obtund sympathetic stimulation from a surgical procedure.
Erik H Hofmeister; Elizabeth B Mackey; Cynthia M Trim
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2007-08-13
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  35     ISSN:  1467-2987     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-23     Completed Date:  2008-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  38-44     Citation Subset:  IM    
Department of Small Animal Medicine & Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
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MeSH Terms
Analgesics, Opioid / administration & dosage,  pharmacology*
Anesthesia, General / veterinary*
Anesthetics, Inhalation / administration & dosage*
Butorphanol / administration & dosage,  pharmacology*
Heart Rate / drug effects
Horses / physiology*,  surgery
Injections, Intravenous / veterinary
Isoflurane / administration & dosage*
Records as Topic
Retrospective Studies
Veterinary Medicine
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Inhalation; 26675-46-7/Isoflurane; 42408-82-2/Butorphanol

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