Document Detail

Effect of buprenorphine on the cardiovascular and respiratory response to visceral pain in conscious rabbits.
MedLine Citation:
PMID:  18282249     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of buprenorphine administration on the cardiovascular and respiratory responses to noxious colorectal distension in conscious rabbits. STUDY DESIGN: Prospective experimental trial. ANIMALS: Fifteen healthy, young adult New Zealand white rabbits (eight female). METHODS: Experiments were performed on conscious rabbits that were instrumented with intraabdominal arterial and venous catheters, and diaphragmatic and abdominal electromyographic electrodes. Colorectal distension was achieved by inflation of an acutely placed colorectal balloon catheter until mean arterial pressure increased 10-15 mmHg. Buprenorphine (0.06 mg) or saline was administered intravenously prior to, or during colorectal distension. Arterial blood pressure, heart rate, respiratory rate, abdominal electromyographic activity, and intra-balloon pressure were monitored. RESULTS: In the absence of colorectal distension, buprenorphine increased arterial blood pressure and decreased respiratory rate but did not change heart rate. Colorectal distension increased arterial blood pressure and heart rate, and decreased respiratory rate. The increase in arterial blood pressure associated with colorectal distension was attenuated following preemptive buprenorphine, but was not changed by buprenorphine administered during distension. CONCLUSIONS AND CLINICAL RELEVANCE: If cardiovascular changes reflect the intensity of noxious stimulation, then these results support the preemptive administration of buprenorphine for visceral analgesia.
Heidi L Shafford; James C Schadt
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-02-18
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  35     ISSN:  1467-2995     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  333-40     Citation Subset:  IM    
Dalton Cardiovascular Research Center & Department of Biomedical Sciences, University of Missouri, 134 Research Park Drive, Columbia, MO 65211, USA.
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MeSH Terms
Analgesics, Opioid / pharmacology*
Balloon Dilatation / veterinary
Blood Gas Analysis / veterinary
Blood Pressure / drug effects,  physiology
Buprenorphine / pharmacology*
Colon / innervation*
Heart Rate / drug effects
Injections, Intravenous / veterinary
Pain, Postoperative / drug therapy,  prevention & control,  veterinary
Rabbits / physiology*
Rectum / innervation*
Respiration / drug effects
Visceral Afferents / physiology
Reg. No./Substance:
0/Analgesics, Opioid; 52485-79-7/Buprenorphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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