Document Detail

Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts.
MedLine Citation:
PMID:  20816812     Owner:  NLM     Status:  MEDLINE    
CONTROL: 59±6%, P<0.05). In the bupivacaine group infarct size was reduced as well (34±3%). In the sevoflurane and bupivacaine-sevoflurane groups the recovery of left ventricular function (+dP/dt) was improved (Sevo: 59±2% and Bupi-Sevo: 59±2% vs.
CONTROL: 47±3%, P<0.05), but not in the bupivacaine group (48±3%). AMPK and GSK3β phosphorylation were increased by sevoflurane but not by bupivacaine. Sevoflurane-induced cardioprotection was not affected by bupivacaine in the non-cardiotoxic range. Bupivacaine alone also reduced infarct size. Both anesthetics activated different signaling kinases, indicating the existence of different cardioprotective intracellular signaling cascades.
R Arthur Bouwman; M Jumoke A Vreden; Nazha Hamdani; Lisan E J Wassenaar; Lonneke Smeding; Stephan A Loer; Ger J M Stienen; Regis R Lamberts
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-09
Journal Detail:
Title:  European journal of pharmacology     Volume:  647     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-04-01     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  132-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthetics, Inhalation / metabolism,  pharmacology*
Anesthetics, Local / metabolism,  pharmacology*
Bupivacaine / metabolism,  pharmacology*
Heart / drug effects*
Heart Diseases / metabolism
Ischemic Preconditioning, Myocardial
Methyl Ethers / metabolism,  pharmacology*
Myocardial Infarction / metabolism
Myocardial Reperfusion
Myocardial Reperfusion Injury / metabolism,  physiopathology,  prevention & control
Protective Agents / metabolism,  pharmacology
Rats, Wistar
Signal Transduction / drug effects*
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Local; 0/Methyl Ethers; 0/Protective Agents; 28523-86-6/sevoflurane; Y8335394RO/Bupivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pachymic acid stimulates glucose uptake through enhanced GLUT4 expression and translocation.
Next Document:  HZ08, a great regulator to reverse multidrug resistance via cycle arrest and apoptosis sensitization...